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Literature summary extracted from

  • Etienne-Grimaldi, M.C.; Francoual, M.; Formento, J.L.; Milano, G.
    Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer (2007), Pharmacogenomics, 8, 1561-1566.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.5.1.20 medicine the consequences of a deficient MTHFR genotype are probably dependent on the folate intake status, there is no clear conclusion regarding the influence of MTHFR polymorphisms on 5-fluorouracil-based treatment in colorectal cancer Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.20 additional information the MTHFR gene polymorphisms C677T and A1298C are associated with altered enzyme activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
 Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.5.1.20 methylenetetrahydrofolate reductase
-
 Homo sapiens
1.5.1.20 MTHFR
-
 Homo sapiens