BRENDA - Enzyme Database

Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs

Kaszaki, J.; Palasthy, Z.; Erczes, D.; Racz, A.; Torday, C.; Varga, G.; Vecsei, L.; Boros, M.; Neurogastroenterol. Motil. 20, 53-62 (2008)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.3.2
additional information
colon obstruction induces a hyperdynamic circulatory reaction, significantly elevated the motility index and increased mucosal leucocyte accumulation and XOR activity, the increase in activity is counteracted by kynurenic acid
Canis lupus familiaris
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.3.2
Kynurenic acid
-
Canis lupus familiaris
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.17.3.2
xanthine + H2O + O2
Canis lupus familiaris
-
urate + H2O2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.17.3.2
Canis lupus familiaris
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.3.2
colon
-
Canis lupus familiaris
-
1.17.3.2
intestine
-
Canis lupus familiaris
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.3.2
xanthine + H2O + O2
-
689189
Canis lupus familiaris
urate + H2O2
-
-
-
?
1.17.3.2
xanthine + H2O + O2
production of superoxide radicals
689189
Canis lupus familiaris
urate + H2O2
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.17.3.2
7.4
-
assay at
Canis lupus familiaris
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.3.2
additional information
colon obstruction induces a hyperdynamic circulatory reaction, significantly elevated the motility index and increased mucosal leucocyte accumulation and XOR activity, the increase in activity is counteracted by kynurenic acid
Canis lupus familiaris
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.3.2
Kynurenic acid
-
Canis lupus familiaris
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.17.3.2
xanthine + H2O + O2
Canis lupus familiaris
-
urate + H2O2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.3.2
colon
-
Canis lupus familiaris
-
1.17.3.2
intestine
-
Canis lupus familiaris
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.3.2
xanthine + H2O + O2
-
689189
Canis lupus familiaris
urate + H2O2
-
-
-
?
1.17.3.2
xanthine + H2O + O2
production of superoxide radicals
689189
Canis lupus familiaris
urate + H2O2
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.17.3.2
7.4
-
assay at
Canis lupus familiaris