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Literature summary extracted from

  • Reyes, D.Y.; Zuber, P.
    Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation (2008), Mol. Microbiol., 69, 765-779.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 Hg2+ potently inhibits (at concentrations of 5-50 nM) TrxR1 activity in both cell-free and intracellular assays Homo sapiens
1.8.1.9 Hg2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens Q16881
-
-
1.8.1.9 Rattus norvegicus O89049
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 THP-1 cell Hg(II) potently inhibits (at concentrations of 5-50 nM) TrxR1 activity in both cell-free and intracellular assays Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Homo sapiens thioredoxin + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Rattus norvegicus thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase-1
-
 Homo sapiens
1.8.1.9 thioredoxin reductase-1
-
 Rattus norvegicus
1.8.1.9 Trx1
-
 Homo sapiens
1.8.1.9 Trx1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Homo sapiens
1.8.1.9 NADPH
-
 Rattus norvegicus