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Literature summary extracted from

  • Thirach, S.; Cooper, C.R.; Vanittanakom, P.; Vanittanakom, N.
    The copper, zinc superoxide dismutase gene of Penicillium marneffei: cloning, characterization, and differential expression during phase transition and macrophage infection (2007), Med. Mycol., 45, 409-417.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.15.1.1 gene sodA, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, semi-quantitative expression analysis Talaromyces marneffei

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+ the residues His47, His49, His64, His72, His81, and Asp121 are involved in metal binding Talaromyces marneffei
1.15.1.1 Zn2+ the residues His47, His49, His64, His72, His81, and Asp121 are involved in metal binding Talaromyces marneffei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 O2.- + H+ Talaromyces marneffei the enzyme contributes to the virulence of many human-pathogenic fungi through its ability to neutralize toxic levels of reactive oxygen species generated by the host O2 + H2O2
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Talaromyces marneffei B6QEB3 gene sodA
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 cell culture propagation of the fungus in the Mus musculus macrophage cell line derived from a reticulum sarcoma, J774.1, ATCC TIB-67, the enzyme expression is upregulated during macrophage infection Talaromyces marneffei
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1.15.1.1 conidium accumulation of sodA mRNA in conidia, semi-quantitative expression analysis Talaromyces marneffei
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1.15.1.1 additional information the enzyme expression is upregulated in the yeast phase Talaromyces marneffei
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1.15.1.1 mycelium semi-quantitative expression analysis, the expression is down regulates in the mycelium phase Talaromyces marneffei
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2.- + H+
-
 Talaromyces marneffei O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ the enzyme contributes to the virulence of many human-pathogenic fungi through its ability to neutralize toxic levels of reactive oxygen species generated by the host Talaromyces marneffei O2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 copper, zinc superoxide dismutase
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 Talaromyces marneffei
1.15.1.1 Cu, Zn SOD
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 Talaromyces marneffei
1.15.1.1 SOD
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 Talaromyces marneffei