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Literature summary extracted from

  • Kazachkov, M.; Chen, Q.; Wang, L.; Zou, J.
    Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling (2008), Lipids, 43, 895-902.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.23 expressed in yeast Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.23 additional information enzyme activity can be inhibited by high levels of acyl acceptors Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.23 0.00045
-
 oleoyl-CoA Vmax: 7.4 pmol/min/microgram protein for oleoyl-CoA Homo sapiens
2.3.1.23 0.005
-
 Arachidonoyl-CoA Vmax: 12.4 pmol/min/microgram protein for arachidonoyl-CoA Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Homo sapiens Q6P1A2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 adipocyte by retrieving LPCAT3 expression pattern from Genevestigator Homo sapiens
-
2.3.1.23 heart northern blot analysis Homo sapiens
-
2.3.1.23 kidney northern blot analysis Homo sapiens
-
2.3.1.23 lung highly expressed, detected by Northern blot analysis Homo sapiens
-
2.3.1.23 pancreas northern blot analysis Homo sapiens
-
2.3.1.23 testis northern blot analysis Homo sapiens
-
2.3.1.23 thymus highly expressed, detected by Northern blot analysis Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.23 additional information
-
 LPCAT3 exhibits the highest activity with lysophosphatidylcholine. LPCAT3 exhibits substrate preferences in the order of 1-stearoyl-2-lysophosphatidylcholine > 1-arachidoyl-2-lysophosphatidylcholine > 1-O-hexadecyl-sn-glycero-3-phosphocholine > 1-palmitoyl-2-lysophosphatidylcholine Homo sapiens
2.3.1.23 additional information
-
 LPCAT3 is most active in utilizing linoleoyl-CoA as acyl donor. Order range: linoleoyl-CoA > palmitoyl-CoA > arachidonoyl-CoA > oleoyl-CoA > stearoyl-CoA Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 arachidonoyl-CoA + 1-arachidoyl-2-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-arachidonoyl-1-arachidoylphosphatidylcholine
-
 ?
2.3.1.23 arachidonoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine LPCAT3 acylates 1-O-alkyl-sn-glycero-3-phosphocholine with arachidonyl-CoA but not with acetyl-CoA Homo sapiens CoA + 2-arachidonoyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.23 arachidonoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-arachidonoyl-1-palmitoylphosphatidylcholine
-
 ?
2.3.1.23 arachidonoyl-CoA + 1-palmitoyl-2-lysophosphatidylethanolamine lysophosphatidylethanolamine acylation is evident. But no significant activity of acylation is detected when 16:0-lysophosphatidylglycerol is used as substrate Homo sapiens CoA + 2-arachidonoyl-1-palmitoylphosphatidylethanolamine
-
 ?
2.3.1.23 arachidonoyl-CoA + 1-stearoyl-2-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-arachidonoyl-1-stearoylphosphatidylcholine
-
 ?
2.3.1.23 arachidonoyl-CoA + palmitoyl-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-arachidonoyl-1-palmitoylphosphatidylcholine
-
 ?
2.3.1.23 linoleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-linoleoyl-1-palmitoylphosphatidylcholine
-
 ?
2.3.1.23 oleoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
-
 ?
2.3.1.23 oleoyl-CoA + palmitoyl-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
-
 ?
2.3.1.23 palmitoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
-
 Homo sapiens CoA + 1,2-dipalmitoylphosphatidylcholine
-
 ?
2.3.1.23 stearoyl-CoA + 1-palmitoyl-2-lysophosphatidylcholine
-
 Homo sapiens CoA + 2-stearoyl-1-palmitoylphosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.23 LPCAT3
-
 Homo sapiens
2.3.1.23 lysophosphatidylcholine acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.23 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.23 7.4
-
 assay at Homo sapiens