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Literature summary extracted from
- Identification and characterization of hamster stearoyl-CoA desaturase isoforms (2008), Lipids, 43, 197-205.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.19.1 | isozyme SCD1, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes | Mesocricetus auratus |
| 1.14.19.1 | isozyme SCD2, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes | Mesocricetus auratus |
| 1.14.19.1 | isozyme SCD3, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes | Mesocricetus auratus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.19.1 | endoplasmic reticulum | - |
Mesocricetus auratus | 5783 | - |
| 1.14.19.1 | membrane | - |
Mesocricetus auratus | 16020 | - |
| 1.14.19.1 | microsome | - |
Mesocricetus auratus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.1 | 40000 | - |
x * 40000, recombinant enzyme, SDS-PAGE | Mesocricetus auratus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Mesocricetus auratus | rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | Mesocricetus auratus | A7LCI9 | gene SCD1; male hamsters, isozyme SCD1 | - |
| 1.14.19.1 | Mesocricetus auratus | A7LCJ0 | gene SCD2; male hamsters, isozyme SCD2 | - |
| 1.14.19.1 | Mesocricetus auratus | Q64420 | gene SCD3 or FAR-17c; male hamsters, isozyme SCD3 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.19.1 | recombinant isozyme SCD1 partially from transfected HEL-293 cells by microsome preparation | Mesocricetus auratus |
| 1.14.19.1 | recombinant isozyme SCD2 partially from transfected HEL-293 cells by microsome preparation | Mesocricetus auratus |
| 1.14.19.1 | recombinant isozyme SCD3 partially from transfected HEL-293 cells by microsome preparation | Mesocricetus auratus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | brain | high expression level of isozyme SCD2 | Mesocricetus auratus | - |
| 1.14.19.1 | liver | - |
Mesocricetus auratus | - |
| 1.14.19.1 | liver | high expression level of isozyme SCD1 | Mesocricetus auratus | - |
| 1.14.19.1 | lung | - |
Mesocricetus auratus | - |
| 1.14.19.1 | additional information | isozyme tissue expression analysis | Mesocricetus auratus | - |
| 1.14.19.1 | additional information | isozyme tissue expression analysis, isoyzme SCD3 shows expression in several tissues | Mesocricetus auratus | - |
| 1.14.19.1 | white adipose tissue | - |
Mesocricetus auratus | - |
| 1.14.19.1 | white adipose tissue | high expression level of isozyme SCD1 | Mesocricetus auratus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Mesocricetus auratus | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview | Mesocricetus auratus | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | ? | x * 40000, recombinant enzyme, SDS-PAGE | Mesocricetus auratus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | SCD | - |
Mesocricetus auratus |
| 1.14.19.1 | stearoyl-CoA desaturase | - |
Mesocricetus auratus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | ferrocytochrome b5 | dependent on, the enzyme also requires the presence of NADH-cytochrome b5 reductase | Mesocricetus auratus | |
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