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Literature summary extracted from

  • Gojo, I.; Tidwell, M.L.; Greer, J.; Takebe, N.; Seiter, K.; Pochron, M.F.; Johnson, B.; Sznol, M.; Karp, J.E.
    Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, in adults with advanced hematologic malignancies (2007), Leuk. Res., 31, 1165-1173.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.2 triapine a potent ribonucleotide reductase inhibitor, phase I and pharmacokinetic study in adults with advanced hematologic malignancies, detailed overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.2 ribonucleoside triphosphate + thioredoxin Homo sapiens
-
 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.2 ribonucleoside triphosphate + thioredoxin
-
 Homo sapiens 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.17.4.2 tetramer alpha2beta2 heterodimer with a regulatory, nucleotide binding site M1 subunit, and an inducible, catalytic M2 subunit which contains non-heme iron and a tyrosyl free radical, that are required for the enzymatic reduction of ribonucleotides Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.17.4.2 ribonucleotide reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.2 thioredoxin
-
 Homo sapiens