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Literature summary extracted from

  • Bratoeff, E.; Sainz, T.; Cabeza, M.; Heuze, I.; Recillas, S.; Perez, V.; Rodriguez, C.; Segura, T.; Gonzales, J.; Ramirez, E.
    Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5alpha-reductase (2007), J. Steroid Biochem. Mol. Biol., 107, 48-56.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione
-
 Homo sapiens
1.3.1.22 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione
-
 Mesocricetus auratus
1.3.1.22 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Homo sapiens
1.3.1.22 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Mesocricetus auratus
1.3.1.22 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Homo sapiens
1.3.1.22 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Mesocricetus auratus
1.3.1.22 dutasteride
-
 Homo sapiens
1.3.1.22 dutasteride
-
 Mesocricetus auratus
1.3.1.22 finasteride
-
 Homo sapiens
1.3.1.22 finasteride
-
 Mesocricetus auratus
1.3.1.22 turosteride
-
 Homo sapiens
1.3.1.22 turosteride
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 cytosol
-
 Homo sapiens 5829
-
1.3.1.22 cytosol
-
 Mesocricetus auratus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-
1.3.1.22 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 prostate gland
-
 Homo sapiens
-
1.3.1.22 prostate gland
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Mesocricetus auratus 5alpha-dihydrotestosterone + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+ + H+
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Mesocricetus auratus 5alpha-dihydrotestosterone + NADP+ + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 steroid 5alpha-reductase
-
 Homo sapiens
1.3.1.22 steroid 5alpha-reductase
-
 Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Homo sapiens
1.3.1.22 NADPH
-
 Mesocricetus auratus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.22 0.0000085
-
 in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 Homo sapiens finasteride
1.3.1.22 0.0000085
-
 with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C Homo sapiens finasteride
1.3.1.22 0.00001
-
 in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 Homo sapiens 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
1.3.1.22 0.00001
-
 with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C Homo sapiens 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
1.3.1.22 0.00005
-
 in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 Homo sapiens 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione
1.3.1.22 0.00005
-
 with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C Homo sapiens 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione