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Literature summary extracted from

  • Olianas, M.C.; Dedoni, S.; Boi, M.; Onali, P.
    Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis and dopamine D1 receptor signaling in rat nucleus accumbens and dorsal striatum (2008), J. Neurochem., 107, 544-556.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 dopamine
-
 Rattus norvegicus
1.14.16.2 nociceptin/orphanin FQ-NOP receptor system activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis and dopamine D1 receptor signaling in rat nucleus accumbens and dorsal striatum, N/OFQ preferentially inhibits phosphoSer40-enzyme in nucleus accumbens shell, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus regulation, overview 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
1.14.16.2 additional information Rattus norvegicus activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis and dopamine D1 receptor signaling in rat nucleus accumbens and dorsal striatum, N/OFQ preferentially inhibits phosphoSer40-enzyme in nucleus accumbens shell, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Rattus norvegicus
-
 male sprague-dawley rats
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.16.2 phosphoprotein reversible phosphorylation at Ser40 is required for enzyme activation, inhibited by the nociceptin/orphanin FQ-NOP receptor system, while phosphorylation on Ser31 is unaffected Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.2 brain nucleus accumbens and dorsal striatum Rattus norvegicus
-
1.14.16.2 corpus striatum dorsal Rattus norvegicus
-
1.14.16.2 nucleus accumbens primary cell culture Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 regulation, overview Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
1.14.16.2 additional information activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis and dopamine D1 receptor signaling in rat nucleus accumbens and dorsal striatum, N/OFQ preferentially inhibits phosphoSer40-enzyme in nucleus accumbens shell, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 tyrosine hydroxylase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.2 tetrahydrobiopterin
-
 Rattus norvegicus