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Literature summary extracted from

  • Massi, P.; Valenti, M.; Vaccani, A.; Gasperi, V.; Perletti, G.; Marras, E.; Fezza, F.; Maccarrone, M.; Parolaro, D.
    5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid (2008), J. Neurochem., 104, 1091-1100.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 ATP
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 cannabidiol
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Ca2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Homo sapiens
-
leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Hordeum vulgare
-
leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2 Homo sapiens
-
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
1.13.11.34 arachidonic acid + O2 Hordeum vulgare
-
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-
1.13.11.34 Hordeum vulgare
-
-
-
3.5.1.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.34 native enzyme to homogeneity from ungerminated seed Hordeum vulgare

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 glioma cell
-
Homo sapiens
-
1.13.11.34 additional information tissue specific expression analysis, overview Hordeum vulgare
-
1.13.11.34 seed ungerminated Hordeum vulgare
-
1.13.11.34 U-87MG cell
-
Homo sapiens
-
3.5.1.4 U-87MG cell cannabidio is able to induce a concentration dependent increase of FAAH activity in U87 cells. A significantly reduced growth rate is observed in FAAH-overexpressing U87 cells, compared to wild-type controls. FAAH mediates the antitumor activity of cannabidiol Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Homo sapiens leukotriene A4 + H2O
-
?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Hordeum vulgare leukotriene A4 + H2O
-
?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Homo sapiens leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Hordeum vulgare leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2
-
Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
1.13.11.34 arachidonic acid + O2
-
Hordeum vulgare (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
Homo sapiens
1.13.11.34 5-lipoxygenase
-
Hordeum vulgare
1.13.11.34 5-LOX
-
Homo sapiens
1.13.11.34 5-LOX
-
Hordeum vulgare
1.13.11.34 arachidonate:oxygen oxidoreductase
-
Homo sapiens
1.13.11.34 arachidonate:oxygen oxidoreductase
-
Hordeum vulgare
3.5.1.4 anandamide hydrolase
-
Homo sapiens
3.5.1.4 FAAH
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.34 37
-
assay at Homo sapiens