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Literature summary extracted from

  • Succol, F.; Pratico, D.
    A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism (2007), J. Neurochem., 103, 380-387.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.31 expression in CHO and in neuro-2 A neuroblastoma cells both stably expressing human APP carrying the K670N/M671L Swedish mutation, expression analysis Homo sapiens
1.13.11.33 expression in CHO and in neuro-2 A neuroblastoma cells both stably expressing human APP carrying the K670N/M671L Swedish mutation, expression analysis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 cinnamyl 3,4-dihydroxy-cyanocinnamate CDC Homo sapiens
1.13.11.31 additional information enzyme inhibition causes a decrease in amyloid-beta protein Homo sapiens
1.13.11.31 PD146176
-
 Homo sapiens
1.13.11.33 cinnamyl 3,4-dihydroxy-cyanocinnamate CDC Homo sapiens
1.13.11.33 additional information enzyme inhibition causes a decrease in amyloid-beta protein Homo sapiens
1.13.11.33 PD146176
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.31 arachidonate + O2 Homo sapiens 12/15-LO protein levels and activity are increased in pathologically affected regions of Alzheimer’s disease brains, enzyme inhibition causes a decrease in amyloid-beta protein, 12/15-LO influences amyloid-beta protein precursor protein metabolism, overview (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.33 arachidonate + O2 Homo sapiens 12/15LO protein levels and activity are increased in pathologically affected regions of Alzheimer’s disease brains, enzyme inhibition causes a decrease in amyloid-beta protein, 12/15LO influences amyloid-beta protein precursor protein metabolism, overview (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
-
-
-
1.13.11.33 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2
-
 Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 12/15-LO protein levels and activity are increased in pathologically affected regions of Alzheimer’s disease brains, enzyme inhibition causes a decrease in amyloid-beta protein, 12/15-LO influences amyloid-beta protein precursor protein metabolism, overview Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 additional information a bifunctional enzyme exhibiting 12-lipoxygenase and 15-lipoxygenase, EC 1.13.11.33, activities Homo sapiens ?
-
 ?
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 arachidonate + O2 12/15LO protein levels and activity are increased in pathologically affected regions of Alzheimer’s disease brains, enzyme inhibition causes a decrease in amyloid-beta protein, 12/15LO influences amyloid-beta protein precursor protein metabolism, overview Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 additional information a bifunctional enzyme exhibiting 15-lipoxygenase and 12-lipoxygenase, EC 1.13.11.31, activities Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12/15 lipoxygenase
-
 Homo sapiens
1.13.11.31 12/15LO
-
 Homo sapiens
1.13.11.33 12/15 lipoxygenase
-
 Homo sapiens
1.13.11.33 12/15LO
-
 Homo sapiens