Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zakharov, V.V.; Mosevitsky, M.I.
    M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3 (2007), J. Neurochem., 101, 1539-1551.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.53 GAP-43-3 a GAP-43 fragment, lacking about 40 N-terminal residues (named GAP-43-3), is produced by m-calpain-mediated cleavage of GAP-43. The fragment prevents complete cleavage of intact GAP-43 by m-calpain as a negative feedback. GAP-43-3 also blocks m-calpain activity against casein Rattus norvegicus
3.4.22.53 GAP-43-3 a GAP-43 fragment, lacking about 40 N-terminal residues (named GAP-43-3), is produced by m-calpain-mediated cleavage of GAP-43. The fragment prevents complete cleavage of intact GAP-43 by m-calpain as a negative feedback. GAP-43-3 also blocks m-calpain activity against casein Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.53 Ca2+ required Rattus norvegicus
3.4.22.53 Ca2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.53 GAP-43 + H2O Rattus norvegicus GAP-43 cleavage at Ser41 residue in synaptosomes is mediated by m-calpain GAP-43-3 + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.53 Rattus norvegicus
-
-
-
3.4.22.53 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.53 brain
-
 Rattus norvegicus
-
3.4.22.53 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.53 casein + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.22.53 casein + H2O
-
 Sus scrofa ?
-
 ?
3.4.22.53 GAP-43 + H2O GAP-43 cleavage at Ser41 residue in synaptosomes is mediated by m-calpain Rattus norvegicus GAP-43-3 + ?
-
 ?
3.4.22.53 GAP-43 + H2O a GAP-43 fragment, lacking about 40 N-terminal residues (named GAP-43-3), is produced by m-calpain. The fragment prevents complete cleavage of intact GAP-43 by m-calpain as a negative feedback Rattus norvegicus GAP-43-3 + ?
-
 ?
3.4.22.53 GAP-43 + H2O a GAP-43 fragment, lacking about 40 N-terminal residues (named GAP-43-3), is produced by m-calpain. The fragment prevents complete cleavage of intact GAP-43 by m-calpain as a negative feedback Sus scrofa GAP-43-3 + ?
-
 ?