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Literature summary extracted from

  • Sebela, M.; Tylichova, M.; Pec, P.
    Inhibition of diamine oxidases and polyamine oxidases by diamine-based compounds (2007), J. Neural Transm., 114, 793-798.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.22 1,4-Diamino-2-butanone potent reversible inhibitors Pisum sativum
1.4.3.22 1,4-Diamino-2-butanone potent reversible inhibitors Sus scrofa
1.4.3.22 1,5-Diamino-3-pentanone potent reversible inhibitors Pisum sativum
1.4.3.22 1,5-Diamino-3-pentanone potent reversible inhibitors Sus scrofa
1.4.3.22 1,6-diamino-3-azahexane competitive Pisum sativum
1.4.3.22 1,8-diamino-3,6-dioxaoctane
-
 Pisum sativum
1.4.3.22 diaminoacetone 0.1 mM, significant inhibition Pisum sativum
1.4.3.22 diaminoacetone 0.1 mM, significant inhibition Sus scrofa
1.4.3.22 diethylenetriamine powerful noncompetitive inhibitor Pisum sativum
1.4.3.22 triethylenetetramine powerful inhibitor Pisum sativum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.22 0.2
-
 1,5-diamino-3-oxapentane
-
 Pisum sativum

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Pisum sativum
-
-
-
1.4.3.22 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.22 kidney
-
 Sus scrofa
-
1.4.3.22 seedling
-
 Pisum sativum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 1,5-diamino-3-oxapentane + H2O + O2 the relative reaction rate with is 13% of that with putrescine Pisum sativum ?
-
 ?
1.4.3.22 1,8-diamino-3,6-dioxaoctane + H2O + O2 the relative reaction rate with is 20% of that with putrescine Pisum sativum ?
-
 ?
1.4.3.22 2-hydroxycadaverine + H2O + O2
-
 Sus scrofa ?
-
 ?
1.4.3.22 2-hydroxycadaverine + H2O + O2
-
 Pisum sativum ?
-
 ?
1.4.3.22 2-hydroxyputrescine + H2O + O2
-
 Sus scrofa ?
-
 ?
1.4.3.22 2-hydroxyputrescine + H2O + O2
-
 Pisum sativum ?
-
 ?
1.4.3.22 3-hydroxycadaverine + H2O + O2
-
 Sus scrofa ?
-
 ?
1.4.3.22 3-hydroxycadaverine + H2O + O2
-
 Pisum sativum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.22 DAO
-
 Sus scrofa
1.4.3.22 DAO
-
 Pisum sativum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.22 0.000015
-
 1,5-Diamino-3-pentanone
-
 Pisum sativum
1.4.3.22 0.0001
-
 1,4-Diamino-2-butanone
-
 Sus scrofa
1.4.3.22 0.0001
-
 1,4-Diamino-2-butanone
-
 Pisum sativum
1.4.3.22 0.0006
-
 triethylenetetramine
-
 Pisum sativum
1.4.3.22 0.0018
-
 1,5-Diamino-3-pentanone
-
 Sus scrofa
1.4.3.22 0.007
-
 diethylenetriamine
-
 Pisum sativum
1.4.3.22 0.012
-
 1,6-diamino-3-azahexane
-
 Pisum sativum
1.4.3.22 0.32
-
 1,8-diamino-3,6-dioxaoctane
-
 Pisum sativum