EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.49 | ATP | 2.0 mM, 65% inhibition, G6PDH-2; G6PDH-1 | Deinococcus radiophilus | |
1.1.1.49 | beta-naphthoquinone-4-sulfonic acid | 1 mM, 68% inhibition, G6PDH-1; 1 mM, 81% inhibition, G6PDH-2 | Deinococcus radiophilus | |
1.1.1.49 | Cd2+ | 1 mM, 53% inhibition, G6PDH-1 | Deinococcus radiophilus | |
1.1.1.49 | Cu2+ | 1 mM, 24% inhibition, G6PDH-1; 1 mM, 78% inhibition, G6PDH-2 | Deinococcus radiophilus | |
1.1.1.49 | EDTA | 5 mM, 85% inhibition, G6PDH-1; 5 mM, 97% inhibition, G6PDH-2 | Deinococcus radiophilus | |
1.1.1.49 | Hg2+ | 1 mM, 47% inhibition, G6PDH-2; 1 mM, 84% inhibition, G6PDH-1 | Deinococcus radiophilus | |
1.1.1.49 | oleic acid | G6PDH-1 is more susceptible to oleic acid than G6PDH-2 | Deinococcus radiophilus | |
1.1.1.49 | Zn2+ | 1 mM, 83% inhibition, G6PDH-2; 1 mM, 94% inhibition, G6PDH-1 | Deinococcus radiophilus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.49 | Ag+ | 1 mM, 1.6fold activation, G6PDH-2 | Deinococcus radiophilus | |
1.1.1.49 | Cd2+ | 1 mM, 1.3fold activation, G6PDH-2 | Deinococcus radiophilus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.49 | 35200 | - |
4 * 35200, G6PDH-1, SDS-PAGE | Deinococcus radiophilus |
1.1.1.49 | 60000 | - |
2 * 60000, G6PDH-2, SDS-PAGE | Deinococcus radiophilus |
1.1.1.49 | 110000 | - |
G6PDH-2, gel filtration | Deinococcus radiophilus |
1.1.1.49 | 130000 | - |
G6PDH-1, gel filtration | Deinococcus radiophilus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.49 | Deinococcus radiophilus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.49 | G6PDH-1 | Deinococcus radiophilus |
1.1.1.49 | G6PDH-2 | Deinococcus radiophilus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.49 | additional information | G6PDH-2 is detected throughout the growth phase | Deinococcus radiophilus | - |
1.1.1.49 | additional information | the enzyme is detected throughout the growth phase. The substantial increase in G6PDH-1 observed at stationary phase or as the results of external oxidative stress indicates that this enzyme is inducible under stressful environmental conditions | Deinococcus radiophilus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.49 | 1033 | - |
cofactor: NADP+, G6PDH-2 | Deinococcus radiophilus |
1.1.1.49 | 1077 | - |
cofactor: NAD+, G6PDH-2 | Deinococcus radiophilus |
1.1.1.49 | 2890 | - |
cofactor: NADP+, G6PDH-1 | Deinococcus radiophilus |
1.1.1.49 | 3078 | - |
cofactor: NAD+, G6PDH-1 | Deinococcus radiophilus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.49 | D-glucose 6-phosphate + NAD+ | - |
Deinococcus radiophilus | D-glucono-1,5-lactone 6-phosphate + NADH + H+ | - |
? | |
1.1.1.49 | D-glucose 6-phosphate + NADP+ | - |
Deinococcus radiophilus | D-glucono-1,5-lactone 6-phosphate + NADPH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.49 | dimer | 2 * 60000, G6PDH-2, SDS-PAGE | Deinococcus radiophilus |
1.1.1.49 | tetramer | 4 * 35200, G6PDH-1, SDS-PAGE | Deinococcus radiophilus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.49 | G6PDH-1 | - |
Deinococcus radiophilus |
1.1.1.49 | G6PDH-2 | - |
Deinococcus radiophilus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.49 | 30 | - |
G6PDH-1 | Deinococcus radiophilus |
1.1.1.49 | 30 | - |
G6PDH-2 | Deinococcus radiophilus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.49 | 70 | - |
30 min, G6PDH-1 retains 40% of its activity | Deinococcus radiophilus |
1.1.1.49 | 70 | - |
30 min, G6PDH-2 retains 35% of its activity | Deinococcus radiophilus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.49 | 8 | - |
G6PDH-1 | Deinococcus radiophilus |
1.1.1.49 | 8 | - |
G6PDH-2 | Deinococcus radiophilus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.49 | NAD+ | dual coenzyme specificity for NAD+ and NADP+, G6PDH-1 | Deinococcus radiophilus | |
1.1.1.49 | NAD+ | dual coenzyme specificity for NAD+ and NADP+, G6PDH-2 | Deinococcus radiophilus | |
1.1.1.49 | NADP+ | dual coenzyme specificity for NAD+ and NADP+, G6PDH-1 | Deinococcus radiophilus | |
1.1.1.49 | NADP+ | dual coenzyme specificity for NAD+ and NADP+, G6PDH-2 | Deinococcus radiophilus |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
1.1.1.49 | Deinococcus radiophilus | isoelectric focusing, pH-range 3-10, G6PDH-2 | - |
5.7 |
1.1.1.49 | Deinococcus radiophilus | isoelectric focusing, pH-range 3-10, G6PDH-1 | - |
6.4 |