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Literature summary extracted from

  • Major, C.A.; Ryan, K.; Bennett, A.J.; Lock, A.L.; Bauman, D.E.; Salter, A.M.
    Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster (2008), J. Lipid Res., 49, 1456-1465.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.1 additional information the enzyme expression is increased by feeding of cholesterol and sterculic oil in parallel, enzyme expression levels and metabolic effects, overview Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 sterculic oil in vivo enzyme inhibition by feeding sterculic oil Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 additional information Mesocricetus auratus inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Mesocricetus auratus
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 male Golden Syrian Hamsters
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 additional information inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview Mesocricetus auratus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD
-
 Mesocricetus auratus
1.14.19.1 stearoyl CoA desaturase
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 Mesocricetus auratus