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Literature summary extracted from
- Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus (2008), J. Ind. Microbiol. Biotechnol., 35, 1-7.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.3 | gene hom, DNA and amino acid sequence determination and analysis, expression in the auxotroph mutant Escherichia coli CGSC 5075 | Streptomyces clavuligerus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.1.1.3 | additional information | construction of a hom disruption mutant by insertional inactivation via double crossover leading to up to 4.3fold and 2fold increases in intracellular free L-lysine concentration and specific cephamycin C production, respectively, during stationary phase in chemically defined medium, overview | Streptomyces clavuligerus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.3 | L-homoserine + NAD(P)+ | Streptomyces clavuligerus | - |
L-aspartate 4-semialdehyde + NAD(P)H | - |
r |  |
| 1.1.1.3 | L-homoserine + NAD(P)+ | Streptomyces clavuligerus NRRL 3585 | - |
L-aspartate 4-semialdehyde + NAD(P)H | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.3 | Streptomyces clavuligerus | Q56R01 | gene hom | - |
| 1.1.1.3 | Streptomyces clavuligerus NRRL 3585 | Q56R01 | gene hom | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.3 | L-homoserine + NAD(P)+ | - |
Streptomyces clavuligerus | L-aspartate 4-semialdehyde + NAD(P)H | - |
r | |
| 1.1.1.3 | L-homoserine + NAD(P)+ | - |
Streptomyces clavuligerus NRRL 3585 | L-aspartate 4-semialdehyde + NAD(P)H | - |
r | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.3 | 22 | - |
assay at room temperature | Streptomyces clavuligerus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.3 | 7 | - |
assay at | Streptomyces clavuligerus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.3 | NADP+ | - |
Streptomyces clavuligerus | |
| 1.1.1.3 | NADPH | - |
Streptomyces clavuligerus | |
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Release 2023.1 (January 2023)
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