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Literature summary extracted from

  • Balbaa, M.; Abdel-Megeed, M.; Diab, T.; Mansour, H.
    Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives (2008), J. Enzyme Inhib. Med. Chem., 23, 483-492.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.2 2-methylquinazolin-4(3H)-one
-
Mus musculus
2.1.3.2 2-phenyl-1,3-4(H)benzothiazin-4-thione noncompetitive inhibitor towards both aspartate and carbamoyl phosphate Mus musculus
2.1.3.2 3-amino-6,8-dibromo-2-methyl-4(3H)-quinazolinone
-
Mus musculus
2.1.3.2 3-amino-6,8-dibromo-2-phenyl-4-(3H)-quinazolinone noncompetitive Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.2 Mus musculus
-
Swiss albino
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.2
-
Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.2 carbamoyl phosphate + L-aspartate
-
Mus musculus phosphate + N-carbamoyl-L-aspartate
-
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Synonyms

EC Number Synonyms Comment Organism
2.1.3.2 aspartate transcarbamylase
-
Mus musculus
2.1.3.2 ATCase
-
Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.3.2 additional information
-
additional information Ki-values at varying concentrations of Asp and carbamoyl phosphate Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.3.2 0.15
-
-
Mus musculus 2-phenyl-1,3-4(H)benzothiazin-4-thione
2.1.3.2 0.18
-
-
Mus musculus 3-amino-6,8-dibromo-2-phenyl-4-(3H)-quinazolinone
2.1.3.2 0.2
-
-
Mus musculus 2-methylquinazolin-4(3H)-one
2.1.3.2 0.35
-
-
Mus musculus 3-amino-6,8-dibromo-2-methyl-4(3H)-quinazolinone