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Literature summary extracted from

  • Shimada, H.; Ohtaguro, M.; Miura, K.; Imamura, Y.
    Inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues (2007), J. Enzyme Inhib. Med. Chem., 22, 445-449.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.149 environmental protection diesel exhaust components are inhibitory on 20alpha-hydroxysteroid dehydrogenase in liver and lung cytosol, with little inhibition in kidney cytosol Mus musculus
1.1.1.149 medicine diesel exhaust components are inhibitory on 20alpha-hydroxysteroid dehydrogenase in liver and lung cytosol, with little inhibition in kidney cytosol Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.149 1,2-naphthoquinone 0.01 mM, 55% inhibition of enzyme in liver, 10% in kidney, 10% in lung cytosolic fraction, respectively Mus musculus
1.1.1.149 9,10-phenanthrenequinone 0.01 mM, 70% inhibition of enzyme in liver, 5% in kidney, 60% in lung cytosolic fraction, respectively Mus musculus
1.1.1.149 apigenin 0.02 mM, 90% inhibition of enzyme in liver cytosolic fraction, 0.05 mM, 45% inhibition in kidney cytosolic fraction Mus musculus
1.1.1.149 fisetin 0.02 mM, 95% inhibition of enzyme in liver cytosolic fraction, 0.05 mM, 20% inhibition in kidney cytosolic fraction Mus musculus
1.1.1.149 kaempferol 0.02 mM, 80% inhibition of enzyme in liver cytosolic fraction, 0.05 mM, 15% inhibition in kidney cytosolic fraction Mus musculus
1.1.1.149 luteolin 0.02 mM, 80% inhibition of enzyme in liver cytosolic fraction, 0.05 mM, 40% inhibition in kidney cytosolic fraction Mus musculus
1.1.1.149 myricetin 0.02 mM, 60% inhibition of enzyme in liver cytosolic fraction, 0.05 mM, 10% inhibition in kidney cytosolic fraction Mus musculus
1.1.1.149 naringenin 0.02 mM, 85% inhibition of enzyme in liver cytosolic fraction, 0.05 mM, 3% inhibition in kidney cytosolic fraction Mus musculus
1.1.1.149 quercetin 0.02 mM, 85% inhibition of enzyme in liver cytosolic fraction, 0.05 mM, 20% inhibition in kidney cytosolic fraction Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.149 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.149 kidney
-
 Mus musculus
-
1.1.1.149 liver
-
 Mus musculus
-
1.1.1.149 lung
-
 Mus musculus
-