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Literature summary extracted from

  • Imamura, Y.; Narumi, R.; Shimada, H.
    Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones (2007), J. Enzyme Inhib. Med. Chem., 22, 105-109.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 butyrophenone inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone Sus scrofa
1.1.1.184 heptanophenone inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone Sus scrofa
1.1.1.184 hexanophenone competitive. Inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone Sus scrofa
1.1.1.184 propiophenone inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone Sus scrofa
1.1.1.184 valerophenone inhibitory potency in decreasing order: hexanophenone, valerophenone, heptanophenone, butyrophenone, propiophenone Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.184 0.037
-
 hexanophenone pH 6.0, 37°C Sus scrofa
1.1.1.184 0.048
-
 valerophenone pH 6.0, 37°C Sus scrofa
1.1.1.184 0.078
-
 heptanophenone pH 6.0, 37°C Sus scrofa
1.1.1.184 0.084
-
 butyrophenone pH 6.0, 37°C Sus scrofa
1.1.1.184 0.249
-
 propiophenone pH 6.0, 37°C Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.184 cytosol
-
 Sus scrofa 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 4-benzoylpyridine + NADPH + H+
-
 Sus scrofa (S)-alpha-phenyl-4-pyridylmethanol + NADP+
-
 ?
1.1.1.184 butyrophenone + NADPH
-
 Sus scrofa 1-phenylbutan-1-ol + NADP+
-
 ?
1.1.1.184 heptanophenone + NADPH
-
 Sus scrofa 1-phenylheptan-1-ol + NADP+
-
 ?
1.1.1.184 hexanophenone + NADPH
-
 Sus scrofa 1-phenylhexan-1-ol + NADP+
-
 ?
1.1.1.184 propiophenone + NADPH
-
 Sus scrofa 1-phenylpropan-1-ol + NADP+
-
 ?
1.1.1.184 valerophenone + NADPH
-
 Sus scrofa 1-phenylpentan-1-ol + NADP+
-
 ?