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Literature summary extracted from

  • Iwata, T.; Yamakoshi, Y.; Hu, J.C.; Ishikawa, I.; Bartlett, J.D.; Krebsbach, P.H.; Simmer, J.P.
    Processing of ameloblastin by MMP-20 (2007), J. Dent. Res., 86, 153-157.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B6 expressed in Escherichia coli XL1-Blue cells Sus scrofa
3.4.24.B6 expression in human kidney 293F cells Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B6 ameloblastin + H2O Sus scrofa MMP-20 processes ameloblastin during the secretory stage of amelogenesis, cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B6 Sus scrofa
-
-
-
3.4.24.B6 Sus scrofa P79287
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.B6
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B6 ameloblastin + H2O MMP-20 cleaves ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222 Sus scrofa ameloblastin fragments fragments of 23 kDa, 17 kDa, and 15 kDa ?
3.4.24.B6 ameloblastin + H2O MMP-20 processes ameloblastin during the secretory stage of amelogenesis, cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage Sus scrofa ?
-
 ?
3.4.24.B6 ameloblastin + H2O cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B6 enamelysin
-
 Sus scrofa
3.4.24.B6 MMP-20
-
 Sus scrofa