Literature summary extracted from

Holm, P.I.; Hustad, S.; Ueland, P.M.; Vollset, S.E.; Grotmol, T.; Schneede, J.
Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->t genotypes and B-vitamin status in a large-scale epidemiological study (2007), J. Clin. Endocrinol. Metab., 92, 1535-1541.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.5.1.20	additional information	the MTHFR gene polymorphism C677T is associated with impaired catalytic properties of the enzyme, betaine is a strong determinant of plasma tHcy in subjects with low serum folate and homozygous C677T genotype	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.5.1.20	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.5.1.20	blood	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.5.1.20	5,10-methylenetetrahydrofolate + reduced acceptor	-	Homo sapiens	5-methyltetrahydrofolate + oxidized acceptor	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.5.1.20	methylenetetrahydrofolate reductase	-	Homo sapiens
1.5.1.20	MTHFR	-	Homo sapiens

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Release 2023.1 (January 2023)