EC Number | Application | Comment | Organism |
---|---|---|---|
1.17.3.2 | pharmacology | the enzyme is a target in treatment of heart failure | Mesocricetus auratus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.3.2 | allopurinol | treatment of TO-2 hamsters with allopurinol inhibits both the decrease in GSH/GSSG ratio and the increase in malondialdehyde levels in the heart | Mesocricetus auratus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.3.2 | xanthine + H2O + O2 | Mesocricetus auratus | xanthine oxidase inhibition, meaning a decrease in myocardial oxidative stress, improves left ventricular dysfunction in dilated cardiomyopathic hamsters, modelling, overview | urate + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.3.2 | Mesocricetus auratus | - |
male TO-2 cardiomyopathic Syrian hamsters | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.3.2 | heart | - |
Mesocricetus auratus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.3.2 | xanthine + H2O + O2 | production of superoxide radicals | Mesocricetus auratus | urate + H2O2 | - |
? | |
1.17.3.2 | xanthine + H2O + O2 | xanthine oxidase inhibition, meaning a decrease in myocardial oxidative stress, improves left ventricular dysfunction in dilated cardiomyopathic hamsters, modelling, overview | Mesocricetus auratus | urate + H2O2 | - |
? |