Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tomida, M.; Ohtake, H.; Yokota, T.; Kobayashi, Y.; Kurosumi, M.
    Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells (2008), J. Cancer Res. Clin. Oncol., 134, 551-559.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.1 pharmacology molecular targets for cancer therapy and diagnosis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.1 expressed in Escherichia coli, NNMT promoter region, promoter-luciferase reporter construct generated, pGL2 vector Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.1 Homo sapiens P40261
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.1 recombinant protein, gel fitration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.1 HEK-293 cell no expression of NNMT in Homo sapiens
-
2.1.1.1 Hep-G2 cell NNMT expression increased on stimulation of the cells with interleukin 6, NNMT promoter activity dependent on the activation of Stat3 Homo sapiens
-
2.1.1.1 HT-29 cell colon cancer cells with high and constitutive expression of NNMT Homo sapiens
-
2.1.1.1 MCF-7 cell no expression of NNMT in Homo sapiens
-
2.1.1.1 MDA-MB-468 cell breast cancer cells with high and constitutive expression of NNMT Homo sapiens
-
2.1.1.1 SW-480 cell colon cancer cells, NNMT expression increased on stimulation of the cells with interleukin 6 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.1 additional information
-
 signal transducers and activators of transcription 3 (Stat3)-regulated genes analyzed, expression of NNMT in cancer cells, promoter activity determined after transfection experiments with NNMT promoter-luciferase reporter construct, real-time PCR, Western-Blot and immunohistochemistry, correlation between the expression of NNMT and activated Stat3 in colon cancer cells, NNMT determined as a Stat3-regulated gene and as a potential tumor marker Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide NNMT as potential candidate for a tumor marker Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.1 NNMT
-
 Homo sapiens