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Literature summary extracted from

  • Muffler, K.; Retzlaff, M.; van Pee, K.H.; Ulber, R.
    Optimisation of halogenase enzyme activity by application of a genetic algorithm (2007), J. Biotechnol., 127, 425-433.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.19.58 pharmacology 5-Br- and 5-Cl-tryptophan could presumably be applied as a pharmacologically attractive precursor of serotonin Streptomyces rugosporus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.58 for expression in Pseudomonas fluorescens Streptomyces rugosporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.58 L-tryptophan + FADH2 + Br- + O2 + H+ Streptomyces rugosporus
-
5-bromo-L-tryptophan + FAD + 2 H2O
-
?
1.14.19.58 L-tryptophan + FADH2 + Cl- + O2 + H+ Streptomyces rugosporus
-
5-chloro-L-tryptophan + FAD + 2 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.58 Streptomyces rugosporus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.19.58 using a nickel-chelating HisTrap HP column Streptomyces rugosporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.58 L-tryptophan + FADH2 + Br- + O2 + H+
-
Streptomyces rugosporus 5-bromo-L-tryptophan + FAD + 2 H2O
-
?
1.14.19.58 L-tryptophan + FADH2 + Cl- + O2 + H+
-
Streptomyces rugosporus 5-chloro-L-tryptophan + FAD + 2 H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.58 halogenase
-
Streptomyces rugosporus
1.14.19.58 trp-5-halogenase
-
Streptomyces rugosporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.19.58 30
-
enzyme assay Streptomyces rugosporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.19.58 7.2
-
enzyme assay Streptomyces rugosporus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.58 FADH2
-
Streptomyces rugosporus