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Literature summary extracted from

  • Yamada-Onodera, K.; Fukui, M.; Tani, Y.
    Purification and characterization of alcohol dehydrogenase reducing N-benzyl-3-pyrrolidinone from Geotrichum capitatum (2007), J. Biosci. Bioeng., 103, 174-178.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.1 1,10-phenanthroline 1 mM, complete inhibition Magnusiomyces capitatus
1.1.1.1 2,2'-bipyridyl 1 mM, 78% inhibition Magnusiomyces capitatus
1.1.1.1 CoCl2 1 mM, 37% inhibition Magnusiomyces capitatus
1.1.1.1 CuCl2 1 mM, complete inhibition Magnusiomyces capitatus
1.1.1.1 FeCl3 0.1 mM, 13% inhibition Magnusiomyces capitatus
1.1.1.1 HgCl2 1 mM, complete inhibition Magnusiomyces capitatus
1.1.1.1 iodoacetic acid 1 mM, 10% inhibition Magnusiomyces capitatus
1.1.1.1 MgCl2 1 mM, 10% inhibition Magnusiomyces capitatus
1.1.1.1 NiCl2 1 mM, complete inhibition Magnusiomyces capitatus
1.1.1.1 PCMB 0.1 mM, complete inhibition Magnusiomyces capitatus
1.1.1.1 ZnSO4 1 mM, complete inhibition Magnusiomyces capitatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 0.13
-
N-benzyl-3-pyrrolidinone pH 6.0 Magnusiomyces capitatus
1.1.1.1 0.79
-
NAD+ pH 8.0 Magnusiomyces capitatus
1.1.1.1 0.87
-
NADH pH 6.0 Magnusiomyces capitatus
1.1.1.1 8.47
-
(S)-N-benzyl-3-pyrrolidinol pH 8.0 Magnusiomyces capitatus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Magnusiomyces capitatus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.1
-
Magnusiomyces capitatus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.1 31
-
-
Magnusiomyces capitatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 1,2-butanediol + NAD+ 35% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 1,2-hexanediol + NAD+ 20% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 1,2-pentanediol + NAD+ 12% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 1,3-butanediol + NAD+ 39% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 1-hexanol + NAD+ 15% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 1-hydroxy-2-butanone + NADH + H+ 59% of the activity with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus butane-1,2-diol + NAD+
-
?
1.1.1.1 1-pentanol + NAD+ 8% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus pentanal + NADH + H+
-
?
1.1.1.1 1-phenyl-1-propanol + NAD+ 31% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 2,3-butanediol + NAD+ 83% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 2,3-butanedione + NADH + H+ activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus ?
-
?
1.1.1.1 2,4-pentanediol + NAD+ 21% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus ?
-
?
1.1.1.1 2-butanol + NAD+ activity is 3.7fold higher than with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus 2-butanone + NADH + H+
-
r
1.1.1.1 2-butanone + NADH + H+ 40% of the activity with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus 2-butanol + NAD+
-
r
1.1.1.1 2-hexanol + NAD+ activity is 11.2fold higher than with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus 2-hexanone + NADH + H+
-
?
1.1.1.1 2-hexanone + NADH + H+ activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus ?
-
?
1.1.1.1 2-pentanol + NAD+ activity is 9fold higher than with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus 2-pentanone + NADH + H+
-
?
1.1.1.1 2-propanol + NAD+ activity is 3.1fold higher than with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus 2-propanone + NADH + H+
-
?
1.1.1.1 3,4-hexanedione + NADH + H+ 77% of the activity with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus ?
-
?
1.1.1.1 acetophenone + NADH + H+ 40% of the activity with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus 1-phenylethanol + NAD+
-
?
1.1.1.1 acetylacetone + NADH + H+ 63% of the activity with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus ?
-
?
1.1.1.1 benzaldehyde + NADH + H+ 74% of the activity with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus benzyl alcohol + NAD+
-
?
1.1.1.1 benzylacetone + NADH + H+ activity is 1.3fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus 4-phenylbutan-2-ol + NAD+
-
?
1.1.1.1 cyclohexanone + NADH + H+ activity is 2.1fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus ?
-
?
1.1.1.1 hydroxyacetone + NADH + H+ 27% of the activity with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus propane-1,2-diol + NAD+
-
?
1.1.1.1 additional information no activity detected with: N-benzyl-2-pyrrolidinone, 2-pyrrolidinone, 3-hexanone, 4-hydroxy-2-butanone, (R)-N-benzyl-3-pyrrolidinol, ethanol, 1,3-propanediol, 1-butanol, 1,4-butanediol, 1,2,3-butanetriol, 1,2,4-butanetriol, acetol, 2-phenyl-1-propanol, 3-phenyl-1-propanol, benzyl alcohol and glycerol. No activity with NADP+ or NADPH Magnusiomyces capitatus ?
-
?
1.1.1.1 N-benzyl-3-pyrrolidinol + NAD+ 33% of the activity with (S)-N-benzyl-3-pyrrolidinol Magnusiomyces capitatus 1-benzylpyrrolidin-3-one + NADH + H+
-
?
1.1.1.1 N-benzyl-3-pyrrolidinone + NADH + H+ (S)-N-benzyl-3-pyrrolidinol is produced at an enantiomeric excess of more than 99.9% Magnusiomyces capitatus (S)-N-benzyl-3-pyrrolidinol + NAD+
-
r
1.1.1.1 n-butylaldehyde + NADH + H+ activity is 1.8fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus butanal + NAD+
-
?
1.1.1.1 n-hexylaldehyde + NADH + H+ activity is 1.6fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus hexanal + NAD+
-
?
1.1.1.1 n-octylaldehyde + NADH + H+ activity is 1.7fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus n-octanol + NAD+
-
?
1.1.1.1 n-valeraldehyde + NADH + H+ activity is 2.8fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus n-pentanol + NAD+
-
?
1.1.1.1 propionaldehyde + NADH + H+ activity is 1.1fold higher than with N-benzyl-3-pyrrolidinone Magnusiomyces capitatus ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.1 30
-
reduction of N-benzyl-3-pyrrolidinone Magnusiomyces capitatus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.1.1.1 20 50 20°C: about 80% of maximal activity, 50°C: about 60% of maximal activity, reduction of N-benzyl-3-pyrrolidinone Magnusiomyces capitatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.1 6 7 reduction of N-benzyl-3-pyrrolidinone Magnusiomyces capitatus