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Literature summary extracted from

  • Petersen, J.; Fisher, K.; Lowe, D.J.
    Structural basis for VO2+ inhibition of nitrogenase activity (A): 31P and 23Na interactions with the metal at the nucleotide binding site of the nitrogenase Fe protein identified by ENDOR spectroscopy (2008), J. Biol. Inorg. Chem., 13, 623-635.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.18.6.1 VO2+ structural basis for VO2+ inhibition of nitrogenase activity, 31P and 23Na interactions with the metal at the nucleotide binding site of the nitrogenase Fe protein identified by ENDOR spectroscopy, vanadyl hyperfine couplings of VO2+-ATP and VO2+-ADP complexes in the presence of the nitrogenase Fe protein, overview Klebsiella pneumoniae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.18.6.1 Fe2+ nitrogenase Fe protein, the FeS cluster exhibits very little change upon MgATP binding, two bound nucleotides are believed to mediate the diverse, functionally essential structural rearrangements in the Fe protein Klebsiella pneumoniae
1.18.6.1 Mg2+ required, the FeS cluster exhibits very little change upon MgATP binding Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.18.6.1 reduced ferredoxin + H+ + N2 + ATP Klebsiella pneumoniae
-
 oxidized ferredoxin + H2 + NH3 + ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.18.6.1 Klebsiella pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.18.6.1 reduced ferredoxin + H+ + N2 + ATP
-
 Klebsiella pneumoniae oxidized ferredoxin + H2 + NH3 + ADP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
1.18.6.1 More Kp2 structure analysis bound to Vo2+, ATP, and ADP, characterization of the metal-nucleotide coordination environment, overview Klebsiella pneumoniae

Synonyms

EC Number Synonyms Comment Organism
1.18.6.1 Kp2
-
 Klebsiella pneumoniae
1.18.6.1 nitrogenase Fe protein
-
 Klebsiella pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
1.18.6.1 ATP the FeS cluster exhibits very little change upon MgATP binding Klebsiella pneumoniae