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Literature summary extracted from

  • Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.
    Identification and characterization of a major liver lysophosphatidylcholine acyltransferase (2008), J. Biol. Chem., 283, 8258-8265.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.23 additional information in a human hepatoma Huh7 cells, RNA interference-mediated knockdown of LPCAT3 results in virtually complete loss of membrane LPCAT activity, suggesting that LPCAT3 is primarily responsible for hepatic LPCAT activity Homo sapiens
2.3.1.23 additional information membranes from HEK293 cells overexpressing LPCAT3 show significantly increased LPCAT activity as assessed by thin layer chromatography analysis with substrate preference toward unsaturated fatty acids Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.23 0.03565
-
stearoyl-CoA Vmax: 996 nmol/min/mg protein Homo sapiens
2.3.1.23 0.04129
-
palmitoyl-CoA Vmax: 1782 nmol/min/mg protein Homo sapiens
2.3.1.23 0.07268
-
oleoyl-CoA Vmax: 4698 nmol/min/mg protein Homo sapiens
2.3.1.23 0.2014
-
linoleoyl-CoA Vmax: 18148 nmol/min/mg protein Homo sapiens
2.3.1.23 0.7156
-
Arachidonoyl-CoA Vmax: 6247 nmol/min/mg protein Homo sapiens
2.3.1.23 0.7219
-
1-palmitoyl-lysophosphatidylcholine Vmax: 6364 nmol/min/mg protein Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.23 endoplasmic reticulum
-
Homo sapiens 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.23 56000
-
deduced from cDNA Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 adipose determined by RT-PCR analysis Homo sapiens
-
2.3.1.23 liver determined by RT-PCR analysis. Furthermore, peroxisome proliferator-activated receptor alpha agonists dose-dependently regulate LPCAT3 in liver in a peroxisome proliferator-activated receptor alpha-dependent fashion Homo sapiens
-
2.3.1.23 pancreas determined by RT-PCR analysis Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.23 additional information
-
among all the different substrates examined, 1-myristoyl-LPC (14:0) and 1-palmitoyl-LPC (16:0) has the most robust activity, whereas no detectable activity is observed using 1-hexanoyl (6:0) and 1-arachidoyl (20:0) LPC as substrates Homo sapiens
2.3.1.23 additional information
-
among the saturated fatty acyl-CoAs, only lauroyl-CoA has comparable activity compared with unsaturated fatty acyl-CoAs. Oleoyl-CoA (18:1), linoleoyl-CoA (18:2), and arachidonoyl-CoA (20:4) all demonstrate robust LPCAT activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 1-myristoyl-lysophosphatidylcholine + palmitoyl-CoA
-
Homo sapiens CoA + 1-myristoyl-2-palmitoylphosphatidylcholine
-
?
2.3.1.23 1-oleoyl-lysophosphatidylcholine + palmitoyl-CoA
-
Homo sapiens CoA + 1-oleoyl-2-palmitoylphosphatidylcholine
-
?
2.3.1.23 1-palmitoyl-lysophosphatidylcholine + arachidonoyl-CoA
-
Homo sapiens CoA + 1-palmitoyl-2-arachidonoylphosphatidylcholine
-
?
2.3.1.23 1-palmitoyl-lysophosphatidylcholine + lauroyl-CoA
-
Homo sapiens CoA + 1-palmitoyl-2-lauroylphosphatidylcholine
-
?
2.3.1.23 1-palmitoyl-lysophosphatidylcholine + linoleoyl-CoA
-
Homo sapiens CoA + 1-palmitoyl-2-linoleoylphosphatidylcholine
-
?
2.3.1.23 1-palmitoyl-lysophosphatidylcholine + n-octanoyl-CoA
-
Homo sapiens CoA + 1-palmitoyl-2-octanoylphosphatidylcholine
-
?
2.3.1.23 1-palmitoyl-lysophosphatidylcholine + oleoyl-CoA
-
Homo sapiens CoA + 2-oleoyl-1-palmitoylphosphatidylcholine
-
?
2.3.1.23 1-palmitoyl-lysophosphatidylcholine + palmitoyl-CoA
-
Homo sapiens CoA + 1,2-dipalmitoylphosphatidylcholine
-
?
2.3.1.23 1-palmitoyl-lysophosphatidylcholine + stearoyl-CoA
-
Homo sapiens CoA + 1-palmitoyl-2-stearoylphosphatidylcholine
-
?
2.3.1.23 1-stearoyl-lysophosphatidylcholine + palmitoyl-CoA
-
Homo sapiens CoA + 1-stearoyl-2-palmitoylphosphatidylcholine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.23 LPCAT3
-
Homo sapiens
2.3.1.23 lysophosphatidylcholine acyltransferase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.23 additional information
-
assay carried out at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.23 7.5
-
assay at Homo sapiens