EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.1.23 | additional information | in a human hepatoma Huh7 cells, RNA interference-mediated knockdown of LPCAT3 results in virtually complete loss of membrane LPCAT activity, suggesting that LPCAT3 is primarily responsible for hepatic LPCAT activity | Homo sapiens |
2.3.1.23 | additional information | membranes from HEK293 cells overexpressing LPCAT3 show significantly increased LPCAT activity as assessed by thin layer chromatography analysis with substrate preference toward unsaturated fatty acids | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.23 | 0.03565 | - |
stearoyl-CoA | Vmax: 996 nmol/min/mg protein | Homo sapiens | |
2.3.1.23 | 0.04129 | - |
palmitoyl-CoA | Vmax: 1782 nmol/min/mg protein | Homo sapiens | |
2.3.1.23 | 0.07268 | - |
oleoyl-CoA | Vmax: 4698 nmol/min/mg protein | Homo sapiens | |
2.3.1.23 | 0.2014 | - |
linoleoyl-CoA | Vmax: 18148 nmol/min/mg protein | Homo sapiens | |
2.3.1.23 | 0.7156 | - |
Arachidonoyl-CoA | Vmax: 6247 nmol/min/mg protein | Homo sapiens | |
2.3.1.23 | 0.7219 | - |
1-palmitoyl-lysophosphatidylcholine | Vmax: 6364 nmol/min/mg protein | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.23 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.23 | 56000 | - |
deduced from cDNA | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.23 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.23 | adipose | determined by RT-PCR analysis | Homo sapiens | - |
2.3.1.23 | liver | determined by RT-PCR analysis. Furthermore, peroxisome proliferator-activated receptor alpha agonists dose-dependently regulate LPCAT3 in liver in a peroxisome proliferator-activated receptor alpha-dependent fashion | Homo sapiens | - |
2.3.1.23 | pancreas | determined by RT-PCR analysis | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.23 | additional information | - |
among all the different substrates examined, 1-myristoyl-LPC (14:0) and 1-palmitoyl-LPC (16:0) has the most robust activity, whereas no detectable activity is observed using 1-hexanoyl (6:0) and 1-arachidoyl (20:0) LPC as substrates | Homo sapiens |
2.3.1.23 | additional information | - |
among the saturated fatty acyl-CoAs, only lauroyl-CoA has comparable activity compared with unsaturated fatty acyl-CoAs. Oleoyl-CoA (18:1), linoleoyl-CoA (18:2), and arachidonoyl-CoA (20:4) all demonstrate robust LPCAT activity | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.23 | 1-myristoyl-lysophosphatidylcholine + palmitoyl-CoA | - |
Homo sapiens | CoA + 1-myristoyl-2-palmitoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-oleoyl-lysophosphatidylcholine + palmitoyl-CoA | - |
Homo sapiens | CoA + 1-oleoyl-2-palmitoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-palmitoyl-lysophosphatidylcholine + arachidonoyl-CoA | - |
Homo sapiens | CoA + 1-palmitoyl-2-arachidonoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-palmitoyl-lysophosphatidylcholine + lauroyl-CoA | - |
Homo sapiens | CoA + 1-palmitoyl-2-lauroylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-palmitoyl-lysophosphatidylcholine + linoleoyl-CoA | - |
Homo sapiens | CoA + 1-palmitoyl-2-linoleoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-palmitoyl-lysophosphatidylcholine + n-octanoyl-CoA | - |
Homo sapiens | CoA + 1-palmitoyl-2-octanoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-palmitoyl-lysophosphatidylcholine + oleoyl-CoA | - |
Homo sapiens | CoA + 2-oleoyl-1-palmitoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-palmitoyl-lysophosphatidylcholine + palmitoyl-CoA | - |
Homo sapiens | CoA + 1,2-dipalmitoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-palmitoyl-lysophosphatidylcholine + stearoyl-CoA | - |
Homo sapiens | CoA + 1-palmitoyl-2-stearoylphosphatidylcholine | - |
? | |
2.3.1.23 | 1-stearoyl-lysophosphatidylcholine + palmitoyl-CoA | - |
Homo sapiens | CoA + 1-stearoyl-2-palmitoylphosphatidylcholine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.23 | LPCAT3 | - |
Homo sapiens |
2.3.1.23 | lysophosphatidylcholine acyltransferase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.23 | additional information | - |
assay carried out at room temperature | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.23 | 7.5 | - |
assay at | Homo sapiens |