Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Perez, J.M.; Arenas, F.A.; Pradenas, G.A.; Sandoval, J.M.; Vasquez, C.C.
    Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes (2008), J. Biol. Chem., 283, 7346-7353.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.2 expression of wild-type and mutant enzymes Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.2 additional information a yqhD knockout mutant does not confer resistance to potassium tellurite and other ROS elicitors Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.67
-
 butanaldehyde pH 7.0, 37°C Escherichia coli
1.1.1.2 1.78
-
 malondialdehyde pH 7.0, 37°C Escherichia coli
1.1.1.2 3.31
-
 propionaldehyde pH 7.0, 37°C Escherichia coli
1.1.1.2 4.81
-
 acrolein pH 7.0, 37°C Escherichia coli
1.1.1.2 28.47
-
 acetaldehyde pH 7.0, 37°C Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 additional information Escherichia coli YqhD mediates resistance to potassium tellurite and other reactive oxygen species elicitors in Escherichia coli, and protects from protein oxidation, YqhD lowers toxic acrolein concentrations, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Escherichia coli
-
 gene yphD
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 acetaldehyde + NADPH + H+
-
 Escherichia coli ethanol + NADP+
-
 r
1.1.1.2 acrolein + NADPH
-
 Escherichia coli propenol + NADP+
-
 r
1.1.1.2 butanaldehyde + NADPH
-
 Escherichia coli butanol + NADP+
-
 r
1.1.1.2 malondialdehyde + NADPH
-
 Escherichia coli ?
-
 r
1.1.1.2 additional information YqhD mediates resistance to potassium tellurite and other reactive oxygen species elicitors in Escherichia coli, and protects from protein oxidation, YqhD lowers toxic acrolein concentrations, overview Escherichia coli ?
-
 ?
1.1.1.2 additional information YqhD does not show any detectable enzymatic activity when tested with short-chain alcohols as substrates, e.g. on methanol, ethanol, propanol, butanol, or isopropanol Escherichia coli ?
-
 ?
1.1.1.2 propanaldehyde + NADPH
-
 Escherichia coli propanol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 NADPH-dependent aldehyde reductase
-
 Escherichia coli
1.1.1.2 YqhD
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.2 37
-
 assay at Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.2 45.1
-
 propionaldehyde pH 7.0, 37°C Escherichia coli
1.1.1.2 53.5
-
 acetaldehyde pH 7.0, 37°C Escherichia coli
1.1.1.2 59.5
-
 butanaldehyde pH 7.0, 37°C Escherichia coli
1.1.1.2 60.1
-
 malondialdehyde pH 7.0, 37°C Escherichia coli
1.1.1.2 62.5
-
 acrolein pH 7.0, 37°C Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 7
-
 assay at Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.2 NADPH dependent on Escherichia coli