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Literature summary extracted from

  • Gao, F.; Koenitzer, J.R.; Tobolewski, J.M.; Jiang, D.; Liang, J.; Noble, P.W.; Oury, T.D.
    Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan (2008), J. Biol. Chem., 283, 6058-6066.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.15.1.1 additional information hyaluronan levels are increased in the bronchoalveolar lavage fluid after asbestos-induced pulmonary injury, and this response is markedly enhanced in EC-SOD knock-out mice, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 extracellular
-
 Mus musculus
-
-
1.15.1.1 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 additional information Homo sapiens EC-SOD protects the lung in both bleomycin- and asbestos-induced models of pulmonary fibrosis ?
-
 ?
1.15.1.1 O2.- + H+ Homo sapiens EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments, thereby preventing activation of polymorphic neutrophil chemotaxis by fragmented hyaluronic acid, overview O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ Mus musculus EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid via its matrix-binding domain and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Homo sapiens
-
-
-
1.15.1.1 Mus musculus
-
 male C57BL/6 mice
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.15.1.1 EC-SOD from aorta Homo sapiens
1.15.1.1 native EC-SOD from mouse lungs by hyaluronic acid affinity chromatography Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 lung high expression level of EC-SOD Mus musculus
-
1.15.1.1 lung high expression level of EC-SOD Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 additional information EC-SOD protects the lung in both bleomycin- and asbestos-induced models of pulmonary fibrosis Homo sapiens ?
-
 ?
1.15.1.1 O2.- + H+
-
 Mus musculus O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+
-
 Homo sapiens O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments, thereby preventing activation of polymorphic neutrophil chemotaxis by fragmented hyaluronic acid, overview Homo sapiens O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid via its matrix-binding domain and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments Mus musculus O2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 EC-SOD
-
 Mus musculus
1.15.1.1 EC-SOD
-
 Homo sapiens
1.15.1.1 extracellular superoxide dismutase
-
 Mus musculus
1.15.1.1 extracellular superoxide dismutase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.15.1.1 22
-
 assay at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.15.1.1 7.4
-
 assay at Homo sapiens