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Literature summary extracted from

  • Christianson, J.L.; Nicoloro, S.; Straubhaar, J.; Czech, M.P.
    Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells (2008), J. Biol. Chem., 283, 2906-2916.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.1 additional information SCD2 mRNA expression is elevated 44fold in adipose tissue upon feeding mice a high fat diet, whereas SCD1 shows little response Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.1 SCD1 and SCD2 expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.19.1 additional information silencing of SCD1 does not downregulate 3T3-L1 cell differentiation or gene expression, inhibition of adipogenesis caused by SCD2 depletion is associated with a decrease in peroxisome proliferator-activated receptor alpha mRNA and protein, whereas in mature adipocytes loss of SCD2 diminishes PPARalpha protein levels, with little change in mRNA levels and protein translation levels Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Mus musculus stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview oleoyl-CoA + ferricytochrome b5 + H2O
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Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 3T3-L1 cell
-
Mus musculus
-
1.14.19.1 adipocyte
-
Mus musculus
-
1.14.19.1 adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O
-
?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
Mus musculus
1.14.19.1 SCD2
-
Mus musculus
1.14.19.1 stearoyl-CoA desaturase 1
-
Mus musculus
1.14.19.1 stearoyl-CoA desaturase 2
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 ferrocytochrome b5
-
Mus musculus