Literature summary extracted from
Henriksson, L.M.; Unge, T.; Carlsson, J.; Aqvist, J.; Mowbray, S.L.; Jones, T.A.
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis (2007), J. Biol. Chem., 282, 19905-19916.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
1.1.1.267 |
expression in Escherichia coli |
Mycobacterium tuberculosis |
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
1.1.1.267 |
wild-type and mutant D151N/E222Q in various complexes with Mn2+, NADPH, and inhibotr fosmidomycin. Asymmetric unit corresponds to biological homodimer. Crystal contacts stabilize an open active site in the B molecule, the A molecule displays closed conformation |
Mycobacterium tuberculosis |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.1.1.267 |
D151N/E222Q |
loss of catalytic ability, loss of binding of Mn2+. Crystallization data |
Mycobacterium tuberculosis |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.1.1.267 |
fosmidomycin |
- |
Mycobacterium tuberculosis |
|
Molecular Weight [Da]
EC Number |
Molecular Weight [Da] |
Molecular Weight Maximum [Da] |
Comment |
Organism |
---|
1.1.1.267 |
41700 |
- |
2 * 41700, calculated and crystallization data |
Mycobacterium tuberculosis |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.1.1.267 |
Mycobacterium tuberculosis |
P9WNS1 |
- |
- |
1.1.1.267 |
Mycobacterium tuberculosis H37Rv |
P9WNS1 |
- |
- |
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
1.1.1.267 |
dimer |
2 * 41700, calculated and crystallization data |
Mycobacterium tuberculosis |
IC50 Value
EC Number |
IC50 Value |
IC50 Value Maximum |
Comment |
Organism |
Inhibitor |
Structure |
---|
1.1.1.267 |
0.00008 |
- |
pH 7.5, 22°C |
Mycobacterium tuberculosis |
fosmidomycin |
|