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Literature summary extracted from

  • Lin, Y.F.; Yang, J.; Rosen, B.P.
    ArsD: an As(III) metallochaperone for the ArsAB As(III)-translocating ATPase (2007), J. Bioenerg. Biomembr., 39, 453-458.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.3.2.7 ArsD ArsD is an arsenic metallochaperone that delivers As(III) to the ArsA ATPase of the ArsAB pump, transferring the trivalent metalloids As(III) and Sb(III) to the ArsA subunit of the pump thereby increasing the affinity of ArsA for As(III), resulting in increased rates if extrusion and resistance to environmentally relevant concentrations of arsenite, mutational analysis of metalloid binding sites involved in As(III) transport and resistance, overview Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.3.2.7 Mg2+
-
Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.3.2.7 ATP + H2O + arsenite/in Escherichia coli ArsA ATPase is the catalytic subunit of the ArsAB pump, ArsD is an arsenic chaperone to the ArsAB pump, transferring the trivalent metalloids As(III) and Sb(III) to the ArsA subunit of the pump thereby increasing the affinity of ArsA for As(III), resulting in increased rates if extrusion and resistance to environmentally relevant concentrations of arsenite ADP + phosphate + arsenite/out
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Organism

EC Number Organism UniProt Comment Textmining
7.3.2.7 Escherichia coli
-
gene arsA encoded on the ars operon on plasmid R773
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.3.2.7 ATP + H2O + arsenite/in ArsA ATPase is the catalytic subunit of the ArsAB pump, ArsD is an arsenic chaperone to the ArsAB pump, transferring the trivalent metalloids As(III) and Sb(III) to the ArsA subunit of the pump thereby increasing the affinity of ArsA for As(III), resulting in increased rates if extrusion and resistance to environmentally relevant concentrations of arsenite Escherichia coli ADP + phosphate + arsenite/out
-
?
7.3.2.7 ATP + H2O + arsenite/in ArsA ATPase is the catalytic subunit of the ArsAB pump Escherichia coli ADP + phosphate + arsenite/out
-
?

Synonyms

EC Number Synonyms Comment Organism
7.3.2.7 ArsAB
-
Escherichia coli
7.3.2.7 As(III)-translocating ATPase
-
Escherichia coli