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Literature summary extracted from

  • Choi, M.M.; Kim, E.A.; Choi, S.Y.; Kim, T.U.; Cho, S.W.; Yang, S.J.
    Inhibitory properties of nerve-specific human glutamate dehydrogenase isozyme by chloroquine (2007), J. Biochem. Mol. Biol., 40, 1077-1082.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.1.3 ADP
-
 Homo sapiens
1.4.1.3 GTP
-
 Homo sapiens
1.4.1.3 L-leucine
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.1.3 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.3 Chloroquine potent inhibitor of isozymes GDH1 and GDH2 at a dose-dependent manner, the inhibitory effect of chloroquine on GDH2 is abolished by the presence of ADP and L-leucine, whereas GTP does not change the sensitivity to chloroquine inhibition, shows a non-competitive inhibition against 2-oxoglutarate and an uncompetitive inhibition against NADH Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.1.3 nerve
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.3 L-glutamate + H2O + NAD(P)+
-
 Homo sapiens 2-oxoglutarate + NH3 + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.1.3 GDH1 housekeeping isozyme Homo sapiens
1.4.1.3 GDH2 nerve-specific isozyme Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.3 NAD(P)+
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.1.3 0.05
-
 GDH1 Homo sapiens Chloroquine
1.4.1.3 0.14
-
 GDH2 Homo sapiens Chloroquine