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Literature summary extracted from

  • Elzainy, T.A.; Ali, T.H.
    Detection of the antitumor glutaminase-asparaginase in the filamentous fungi (2006), J. Appl. Sci., 6, 1389-1395.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.38 additional information use of phosphate buffer yields higher activities than Tris, phthalate, or citrate buffer, optimum concentration is 0.08 - 0.16 M phosphate Aspergillus niger

Application

EC Number Application Comment Organism
3.5.1.38 drug development enzyme could possibly be used as an anti-tumor therapeutic agent Aspergillus niger

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.38 Hg2+
-
Aspergillus niger
3.5.1.38 Mg2+
-
Aspergillus niger
3.5.1.38 additional information no product inhibition Aspergillus niger

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.38 0.0026
-
L-asparagine pH6, 40°C Aspergillus niger
3.5.1.38 0.0051
-
L-glutamine pH6, 40°C Aspergillus niger
3.5.1.38 2.57
-
L-asparagine
-
Aspergillus niger
3.5.1.38 5.05
-
L-glutamine
-
Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.38 L-asparagine + H2O Aspergillus niger involved in the maintenance of the correct L-asparagine/L-aspartate ratio L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O Penicillium chrysogenum involved in the maintenance of the correct L-asparagine/L-aspartate ratio L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O Penicillium palitans involved in the maintenance of the correct L-asparagine/L-aspartate ratio L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O Aspergillus niger NRRL 3 involved in the maintenance of the correct L-asparagine/L-aspartate ratio L-aspartate + NH3
-
?
3.5.1.38 L-glutamine + H2O Aspergillus niger involved in the maintenance of the correct L-glutamine/L-glutamate ratio L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O Penicillium chrysogenum involved in the maintenance of the correct L-glutamine/L-glutamate ratio L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O Penicillium palitans involved in the maintenance of the correct L-glutamine/L-glutamate ratio L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O Aspergillus niger NRRL 3 involved in the maintenance of the correct L-glutamine/L-glutamate ratio L-glutamate + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.38 Aspergillus niger
-
NRRL3
-
3.5.1.38 Aspergillus niger
-
highest activity in 4 days old nitrate-grown mats
-
3.5.1.38 Aspergillus niger NRRL 3
-
NRRL3
-
3.5.1.38 Aspergillus niger NRRL 3
-
highest activity in 4 days old nitrate-grown mats
-
3.5.1.38 Penicillium chrysogenum
-
-
-
3.5.1.38 Penicillium chrysogenum
-
nitrate-grown mat
-
3.5.1.38 Penicillium palitans
-
-
-
3.5.1.38 Penicillium palitans
-
nitrate-grown mat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.38
-
Aspergillus niger

Storage Stability

EC Number Storage Stability Organism
3.5.1.38 activity is retained in the freezer for some months Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.38 D-asparagine + H2O
-
Aspergillus niger D-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O involved in the maintenance of the correct L-asparagine/L-aspartate ratio Aspergillus niger L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O involved in the maintenance of the correct L-asparagine/L-aspartate ratio Penicillium chrysogenum L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O involved in the maintenance of the correct L-asparagine/L-aspartate ratio Penicillium palitans L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O ratio of glutaminase to aspariginase activity is 0.7 to 1 Aspergillus niger L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O ratio of glutaminase to aspariginase activity is 0.8 to 1 Penicillium palitans L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O ratio of glutaminase to aspariginase activity is 1.4 to 1 Penicillium chrysogenum L-aspartate + NH3
-
?
3.5.1.38 L-asparagine + H2O involved in the maintenance of the correct L-asparagine/L-aspartate ratio Aspergillus niger NRRL 3 L-aspartate + NH3
-
?
3.5.1.38 L-glutamine + H2O
-
Aspergillus niger L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O involved in the maintenance of the correct L-glutamine/L-glutamate ratio Aspergillus niger L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O involved in the maintenance of the correct L-glutamine/L-glutamate ratio Penicillium chrysogenum L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O involved in the maintenance of the correct L-glutamine/L-glutamate ratio Penicillium palitans L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O ratio of glutaminase to aspariginase activity is 0.7 to 1 Aspergillus niger L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O ratio of glutaminase to aspariginase activity is 0.8 to 1 Penicillium palitans L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O ratio of glutaminase to aspariginase activity is 1.4 to 1 Penicillium chrysogenum L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O
-
Aspergillus niger NRRL 3 L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O involved in the maintenance of the correct L-glutamine/L-glutamate ratio Aspergillus niger NRRL 3 L-glutamate + NH3
-
?
3.5.1.38 L-glutamine + H2O ratio of glutaminase to aspariginase activity is 0.7 to 1 Aspergillus niger NRRL 3 L-glutamate + NH3
-
?
3.5.1.38 additional information acetamide, nicotinamide, and NAD are not hydrolyzed Aspergillus niger ?
-
?
3.5.1.38 additional information acetamide, nicotinamide, and NAD are not hydrolyzed Penicillium chrysogenum ?
-
?
3.5.1.38 additional information acetamide, nicotinamide, and NAD are not hydrolyzed Penicillium palitans ?
-
?
3.5.1.38 additional information acetamide, nicotinamide, and NAD are not hydrolyzed Aspergillus niger NRRL 3 ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.38 50
-
-
Penicillium chrysogenum
3.5.1.38 60
-
-
Aspergillus niger

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.5.1.38 30 80
-
Aspergillus niger

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.1.38 40
-
30 min, about 10% loss of activity Aspergillus niger
3.5.1.38 50
-
30 min, about 40% loss of activity Aspergillus niger
3.5.1.38 60
-
30 min, about 70% loss of activity Aspergillus niger
3.5.1.38 60
-
incubation at 60°C in the absence of substrate for 20 min causes a 70% increase in activity Aspergillus niger

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.38 4
-
activity is higher in phosphate buffer than in citrate buffer Aspergillus niger
3.5.1.38 6 7
-
Penicillium chrysogenum
3.5.1.38 6
-
-
Aspergillus niger

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.1.38 4 9
-
Aspergillus niger