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Literature summary extracted from

  • Fujikawa, Y.; Urano, Y.; Komatsu, T.; Hanaoka, K.; Kojima, H.; Terai, T.; Inoue, H.; Nagano, T.
    Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells (2008), J. Am. Chem. Soc., 130, 14533-14543.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.18 expressed in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.18 0.232
-
 3,4-dinitrobenzanilide in phosphate buffered saline, pH 7.4, at 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Homo sapiens P09211
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 A-549 cell
-
 Homo sapiens
-
2.5.1.18 HeLa cell
-
 Homo sapiens
-
2.5.1.18 HL-60 cell
-
 Homo sapiens
-
2.5.1.18 HT-1080 cell
-
 Homo sapiens
-
2.5.1.18 HuCCT-1 cell
-
 Homo sapiens
-
2.5.1.18 HUVEC cell
-
 Homo sapiens
-
2.5.1.18 OUS-11 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 4-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
-
 Homo sapiens ?
-
 ?
2.5.1.18 5-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens S-(2,4-dinitrophenyl)glutathione + HCl
-
 ?
2.5.1.18 glutathione + 2-methyl-4-nitrobenzyl alcohol
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + 3,4-dinitrobenzanilide
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + 4-chloro-3-nitroacetophenone
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + 4-chloro-3-nitrobenzophenone
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + 4-fluoro-3-nitrobenzanilide
-
 Homo sapiens ?
-
 ?
2.5.1.18 additional information pentafluorobenzanilide and 4-chloro-3-nitrobenzanilide are no substrates Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.18 glutathione S-transferase
-
 Homo sapiens
2.5.1.18 GSTP1
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.18 367
-
 3,4-dinitrobenzanilide in phosphate buffered saline, pH 7.4, at 37°C Homo sapiens