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Literature summary extracted from

  • Dey, A.; Jenney, F.E.; Adams, M.W.; Johnson, M.K.; Hodgson, K.O.; Hedman, B.; Solomon, E.I.
    Sulfur K-edge X-ray absorption spectroscopy and density functional theory calculations on superoxide reductase: role of the axial thiolate in reactivity (2007), J. Am. Chem. Soc., 129, 12418-12431.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.15.1.2 additional information
-
 additional information kinetic analysis, binding parameters, and electrochemic parameters of the enzyme and Fe2+ complexes, overview Pyrococcus furiosus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.2 Fe2+ 1Fe SOR is a non-heme iron enzyme, iron binding and reaction mechanism, detailed overview Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.2 reduced rubredoxin + superoxide + H+ Pyrococcus furiosus
-
 rubredoxin + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.2 Pyrococcus furiosus P82385
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.15.1.2 superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin reaction mechanism of SOR involving transfer of an electron and two protons to superoxide to form hydrogen peroxide, kinetic mechanism, detailed overview Pyrococcus furiosus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.2 reduced rubredoxin + superoxide + H+
-
 Pyrococcus furiosus rubredoxin + H2O2
-
 ?
1.15.1.2 reduced rubredoxin + superoxide + H+ SOR is a non-heme iron enzyme that reduces superoxide to peroxide at a diffusion-controlled rate, thiolate acts as a covalent anionic ligand. Replacing the thiolate with a neutral noncovalent ligand makes protonation very endothermic and greatly raises the reduction potential,overview Pyrococcus furiosus rubredoxin + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.2 1Fe SOR
-
 Pyrococcus furiosus
1.15.1.2 SOR
-
 Pyrococcus furiosus

Cofactor

EC Number Cofactor Comment Organism Structure
1.15.1.2 reduced rubredoxin
-
 Pyrococcus furiosus