Any feedback?
Literature summary extracted from
- Regulation of lipoxygenase activity by polyunsaturated lysophosphatidylcholines or their oxygenation derivatives (2008), J. Agric. Food Chem., 56, 7808-7814.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.34 | (13S)-hydroperoxy-9,11-octadecadienoic acid | - |
Solanum tuberosum |  |
| 1.13.11.34 | (13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine | 50% activation concentration AC50 is 0.0015 mM | Solanum tuberosum | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.34 | (15S)-hydroperoxy-5,8,11,13-eicosatetraenoyl lysophosphatidylcholine | - |
Solanum tuberosum | |
| 1.13.11.34 | (17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine | - |
Solanum tuberosum | |
| 1.13.11.34 | arachidonoyl lysophosphatidylcholine | - |
Solanum tuberosum | |
| 1.13.11.34 | additional information | no inhibition by 1-linoleoyl lysophosphatidylcholine and (13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine | Solanum tuberosum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Solanum tuberosum | - |
leukotriene A4 + H2O | - |
? | |
| 1.13.11.34 | arachidonic acid + O2 | Solanum tuberosum | - |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | Solanum tuberosum | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | commercial preparation | - |
Solanum tuberosum | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Solanum tuberosum | leukotriene A4 + H2O | - |
? | |
| 1.13.11.34 | arachidonic acid + O2 | - |
Solanum tuberosum | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | 5-lipoxygenase | - |
Solanum tuberosum |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.34 | 25 | - |
assay at | Solanum tuberosum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.34 | 6.3 | - |
assay at | Solanum tuberosum |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.11.34 | additional information | - |
additional information | inhibition kinetics, overview | Solanum tuberosum | |
| 1.13.11.34 | 0.00038 | - |
arachidonoyl lysophosphatidylcholine | pH 6.3, 25°C | Solanum tuberosum | |
| 1.13.11.34 | 0.0019 | - |
(17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine | pH 6.3, 25°C | Solanum tuberosum | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.13.11.34 | 0.0166 | - |
pH 6.3, 25°C | Solanum tuberosum | arachidonoyl lysophosphatidylcholine | |
| 1.13.11.34 | 0.0241 | - |
pH 6.3, 25°C | Solanum tuberosum | (17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
