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Literature summary extracted from

  • Stachowska, E.; Dziedziejko, V.; Safranow, K.; Jakubowska, K.; Olszewska, M.; Machalinski, B.; Chlubek, D.
    Effect of conjugated linoleic acids on the activity and mRNA expression of 5- and 15-lipoxygenases in human macrophages (2007), J. Agric. Food Chem., 55, 5335-5342.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.33 additional information linoleic acid induces 15-LO-1 expression 2.6fold Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 conjugated linoleic acids conjugated linoleic acids may function as inhibitors of 15-LO-1 activity in macrophages/in vivo, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Homo sapiens
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
 isozyme 15-LO-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 macrophage isozyme 15-LO-1, differentiated monocytes obtained from human venous blood, CD14+ Homo sapiens
-
1.13.11.33 THP-1 cell CD14+ Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 additional information conjugated linoleic acids are no substrates for 15-LO-1 in vitro, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase
-
 Homo sapiens
1.13.11.33 15-LO
-
 Homo sapiens