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Literature summary extracted from

  • Aggarwal, N.T.; Chawengsub, Y.; Gauthier, K.M.; Viita, H.; Yla-Herttuala, S.; Campbell, W.B.
    Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits (2008), Hypertension, 51, 246-251.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.33 overexpression of isozyme 15-LO-1 in Oryctolagus cuniculus via adenovirus transfection method, the expression is restricted to aortic endothelial cells, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.33 additional information endothelial 15-lipoxygenase-1 overexpression in Oryctolagus cuniculus aortic endothelial cells increases acetylcholine-induced hypotension and vasorelaxation, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Homo sapiens arachidonic acid is metabolized by the 15-lipoxygenase-1 pathway to the vasodilatory eicosanoids hydroxyepoxyeicosatrienoic acid and trihydroxyeicosatrienoic acid (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
 isozyme 15-LO-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 endothelial cell endothelial 15-LO-1 isozyme Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 arachidonate + O2 arachidonic acid is metabolized by the 15-lipoxygenase-1 pathway to the vasodilatory eicosanoids hydroxyepoxyeicosatrienoic acid and trihydroxyeicosatrienoic acid Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 endothelial 15-lipoxygenase-1
-
 Homo sapiens