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Literature summary extracted from

  • Gemmati, D.; Ongaro, A.; Tognazzo, S.; Catozzi, L.; Federici, F.; Mauro, E.; Della Porta, M.; Campioni, D.; Bardi, A.; Gilli, G.; Pellati, A.; Caruso, A.; Scapoli, G.L.; De Mattei, M.
    Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkins lymphoma patients: association with toxicity and survival (2007), Haematologica, 92, 478-485.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.20 additional information MTHFR C677T and A1298C gene variants play a critical role in NHL outcome, possibly by interfering with the action of methotrexate with significant effects on toxicity and survival in non-Hodgkin's lymphoma patients Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.20 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
 Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.20 methylenetetrahydrofolate reductase
-
 Homo sapiens
1.5.1.20 MTHFR
-
 Homo sapiens