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Literature summary extracted from

  • Flück, C.E.; Nicolo, C.; Pandey, A.V.
    Clinical, structural and functional implications of mutations and polymorphisms in human NADPH P450 oxidoreductase (2007), Fundam. Clin. Pharmacol., 21, 399-410.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.6.2.4 A115V Vmax/Km for cytochrome c is 63% of wild-type value, Vmax/Km for NADPH is 41% of wild-type value Homo sapiens
1.6.2.4 A287P Vmax/Km for cytochrome c is 9% of wild-type value, Vmax/Km for NADPH is 16% of wild-type value Homo sapiens
1.6.2.4 A503V Vmax/Km for cytochrome c is 69% of wild-type value, Vmax/Km for NADPH is 86% of wild-type value Homo sapiens
1.6.2.4 C569Y Vmax/Km for cytochrome c is 6% of wild-type value, Vmax/Km for NADPH is 2% of wild-type value Homo sapiens
1.6.2.4 F646del Vmax/Km for cytochrome c is 36% of wild-type value, Vmax/Km for NADPH is 94% of wild-type value Homo sapiens
1.6.2.4 G413S Vmax/Km for cytochrome c is 76% of wild-type value, Vmax/Km for NADPH is identical to wild-type value Homo sapiens
1.6.2.4 G504R Vmax/Km for cytochrome c is 53% of wild-type value, Vmax/Km for NADPH is 47% of wild-type value Homo sapiens
1.6.2.4 G539R Vmax/Km for cytochrome c is 9% of wild-type value, Vmax/Km for NADPH is 0.2% of wild-type value Homo sapiens
1.6.2.4 L565P Vmax/Km for cytochrome c is 14% of wild-type value, Vmax/Km for NADPH is 1.4% of wild-type value Homo sapiens
1.6.2.4 M263V Vmax/Km for cytochrome c is 76% of wild-type value, Vmax/Km for NADPH is 57% of wild-type value Homo sapiens
1.6.2.4 P228L Vmax/Km for cytochrome c is 75% of wild-type value, Vmax/Km for NADPH is 72% of wild-type value Homo sapiens
1.6.2.4 Q153R Vmax/Km for cytochrome c is 9% of wild-type value, Vmax/Km for NADPH is 11% of wild-type value Homo sapiens
1.6.2.4 R316W Vmax/Km for cytochrome c is 61% of wild-type value, Vmax/Km for NADPH is 77% of wild-type value Homo sapiens
1.6.2.4 R457H Vmax/Km for cytochrome c is 0.7% of wild-type value Homo sapiens
1.6.2.4 T142A Vmax/Km for cytochrome c is 49% of wild-type value, Vmax/Km for NADPH is 52% of wild-type value Homo sapiens
1.6.2.4 V492E Vmax/Km for cytochrome c is 0.3% of wild-type value Homo sapiens
1.6.2.4 V608F Vmax/Km for cytochrome c is 8% of wild-type value, Vmax/Km for NADPH is 3% of wild-type value Homo sapiens
1.6.2.4 V631I Vmax/Km for cytochrome c is 74% of wild-type value, Vmax/Km for NADPH is 23% of wild-type value Homo sapiens
1.6.2.4 Y459H Vmax/Km for cytochrome c is 0.4% of wild-type value Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 2 ferricytochrome c + NADPH
-
 Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.4 NADPH P450 oxidoreductase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6.2.4 0.43
-
 ferricytochrome c mutant enzyme Y459H Homo sapiens
1.6.2.4 0.47
-
 ferricytochrome c mutant enzyme V492E Homo sapiens
1.6.2.4 0.5
-
 ferricytochrome c mutant enzyme R457H Homo sapiens
1.6.2.4 0.67
-
 NADPH mutant enzyme G539R Homo sapiens
1.6.2.4 0.87
-
 NADPH mutant enzyme C569Y Homo sapiens
1.6.2.4 1.5
-
 ferricytochrome c mutant enzyme Q153R Homo sapiens
1.6.2.4 1.7
-
 NADPH mutant enzyme L565P Homo sapiens
1.6.2.4 1.73
-
 ferricytochrome c mutant enzyme C569Y Homo sapiens
1.6.2.4 1.87
-
 ferricytochrome c mutant enzyme L565P Homo sapiens
1.6.2.4 1.87
-
 ferricytochrome c mutant enzyme V608F Homo sapiens
1.6.2.4 2.3
-
 NADPH mutant enzyme V608F Homo sapiens
1.6.2.4 2.3
-
 NADPH mutant enzyme V631I Homo sapiens
1.6.2.4 2.5
-
 NADPH mutant enzyme A287P Homo sapiens
1.6.2.4 2.6
-
 NADPH mutant enzyme A115V Homo sapiens
1.6.2.4 2.6
-
 ferricytochrome c mutant enzyme A287P Homo sapiens
1.6.2.4 2.7
-
 ferricytochrome c mutant enzyme G539R Homo sapiens
1.6.2.4 2.97
-
 NADPH mutant enzyme T142A Homo sapiens
1.6.2.4 3.1
-
 NADPH mutant enzyme Q153R Homo sapiens
1.6.2.4 3.6
-
 ferricytochrome c mutant enzyme T142A Homo sapiens
1.6.2.4 3.63
-
 NADPH mutant enzyme G504R Homo sapiens
1.6.2.4 3.8
-
 NADPH mutant enzyme P228L Homo sapiens
1.6.2.4 3.97
-
 NADPH mutant enzyme A503V Homo sapiens
1.6.2.4 4.3
-
 NADPH mutant enzyme F646del Homo sapiens
1.6.2.4 4.4
-
 NADPH mutant enzyme G413S Homo sapiens
1.6.2.4 4.6
-
 ferricytochrome c mutant enzyme G413S Homo sapiens
1.6.2.4 4.87
-
 NADPH wild-type enzyme Homo sapiens
1.6.2.4 4.9
-
 NADPH mutant enzyme M263V Homo sapiens
1.6.2.4 4.9
-
 ferricytochrome c mutant enzyme P228L Homo sapiens
1.6.2.4 4.9
-
 NADPH mutant enzyme R316W Homo sapiens
1.6.2.4 5.2
-
 ferricytochrome c mutant enzyme G504R Homo sapiens
1.6.2.4 5.4
-
 ferricytochrome c mutant enzyme R316W Homo sapiens
1.6.2.4 5.47
-
 ferricytochrome c mutant enzyme V631I Homo sapiens
1.6.2.4 5.73
-
 ferricytochrome c mutant enzyme A503V Homo sapiens
1.6.2.4 5.8
-
 ferricytochrome c mutant enzyme A115V Homo sapiens
1.6.2.4 6.4
-
 ferricytochrome c mutant enzyme F646del Homo sapiens
1.6.2.4 6.47
-
 ferricytochrome c wild-type enzyme Homo sapiens
1.6.2.4 6.7
-
 ferricytochrome c mutant enzyme M263V Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.4 FAD
-
 Homo sapiens
1.6.2.4 FMN
-
 Homo sapiens
1.6.2.4 NADPH
-
 Homo sapiens