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Literature summary extracted from

  • Sundaramoorthy, R.; Iulek, J.; Barrett, M.P.; Bidet, O.; Ruda, G.F.; Gilbert, I.H.; Hunter, W.N.
    Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates (2007), FEBS J., 274, 275-286.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.44 medicine 6-phosphogluconate dehydrogenase is a potential target for new drugs against African trypanosomiasis Trypanosoma brucei

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.44
-
 Trypanosoma brucei
1.1.1.44 crystal structures of recombinant Lactococcus lactis 6-phosphogluconate dehydrogenase in complex with substrate, cofactor, product and inhibitors Lactococcus lactis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 4-phospho-D-erythronate mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state Trypanosoma brucei
1.1.1.44 4-phospho-D-erythronohydroxamic acid
-
 Lactococcus lactis
1.1.1.44 5-phospho-D-ribonate substrate analogue Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.00013
-
 6-phospho-D-gluconate
-
 Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Lactococcus lactis P96789
-
-
1.1.1.44 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Lactococcus lactis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Trypanosoma brucei D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Trypanosoma brucei
1.1.1.44 LlPDH
-
 Lactococcus lactis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.44 0.00013
-
 4-phospho-D-erythronate
-
 Trypanosoma brucei
1.1.1.44 0.00095
-
 5-phospho-D-ribonate
-
 Trypanosoma brucei