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Literature summary extracted from

  • Chwatko, G.; Boers, G.H.; Strauss, K.A.; Shih, D.M.; Jakubowski, H.
    Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice (2007), FASEB J., 21, 1707-1713.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.20 R377C the mutation increases plasma homocysteine thiolactone levels 59fold Mus musculus
1.5.1.20 R377C the mutation increases plasma homocysteine thiolactone levels 59fold Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Homo sapiens
-
-
-
1.5.1.20 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.20 blood
-
Mus musculus
-
1.5.1.20 blood
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
Mus musculus 5-methyltetrahydrofolate + oxidized acceptor
-
?
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.20 methylenetetrahydrofolate reductase
-
Mus musculus
1.5.1.20 methylenetetrahydrofolate reductase
-
Homo sapiens
1.5.1.20 MTHFR
-
Mus musculus
1.5.1.20 MTHFR
-
Homo sapiens