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Literature summary extracted from

  • Matthiesen, S.; Lindemann, D.; Warnken, M.; Juergens, U.R.; Racke, K.
    Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages (2008), Eur. J. Pharmacol., 579, 403-410.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.3.1 lipopolysaccharide 0.001 mg/ml cause a 2fold increase in arginase activity and a marked increase in mRNA encoding arginase I Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 apocynin inhibition of NAD(P)H oxidase in alveolar macrophage by apocynin results in down-regulation of arginase activity and decrease in arginase I mRNA Rattus norvegicus
3.5.3.1 cycloheximide inhibits protein synthesis Rattus norvegicus
3.5.3.1 additional information ebselen does not inhibit arginase, apocynin does not affect the stability of arginase I mRNA but accelerates the decline of arginase activity when protein synthesis is inhibited by cycloheximide Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.1 L-arginine + H2O Rattus norvegicus
-
L-ornithine + urea
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Rattus norvegicus
-
-
-
3.5.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 macrophage alveolar macrophages. Inhibition of NAD(P)H oxidase by apocynin results in down-regulation of arginase Rattus norvegicus
-
3.5.3.1 macrophage alveolar macrophage Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.1 L-arginine + H2O
-
Rattus norvegicus L-ornithine + urea
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.1 arginase I
-
Rattus norvegicus