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Literature summary extracted from

  • Prost, J.; Belleville, J.; Bouchenak, M.
    Serum lecithin: cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns (2008), Eur. J. Pediatr., 167, 525-532.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.43 medicine it is shown that LCAT activity is lower in pregnancy induced hypertension (PIH) and chronic hypertensive (CH) mothers than in normotensive controls. Similar changes are observed in small for gestational age (SGA) newborns of PHI mothers and in SGA newborns of CH mothers when compared to appropriate for gestational age newborns of control mothers (AGA-NC) Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.43 additional information HDL2 and HDL3-phospholipids, HDL2-cholesterol concentrations and LCAT activity are reduced in preganancy-induced hypertension and in chronic hypertensive mothers, as well as in their small for gestational age, SGA, newborns. Maternal hypertension and foetal intrauterine growth retardation are associated with profound abnormalities in HDL metabolism, consistent with an atherogenic risk, phenotype, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 additional information Homo sapiens HDL2 and HDL3-phospholipids, HDL2-cholesterol concentrations and LCAT activity are reduced in preganancy-induced hypertension and in chronic hypertensive mothers, as well as in their small for gestational age, SGA, newborns, overview ?
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood
-
 Homo sapiens
-
2.3.1.43 blood plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 additional information
-
 LCAT activity in parallel with HDL2 and HDL3 amounts and composition in pregnancy induced hypertension and chronic hypertensive mothers and in their small newborns, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information HDL2 and HDL3-phospholipids, HDL2-cholesterol concentrations and LCAT activity are reduced in preganancy-induced hypertension and in chronic hypertensive mothers, as well as in their small for gestational age, SGA, newborns, overview Homo sapiens ?
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin-cholesterol acyltransferase
-
 Homo sapiens
2.3.1.43 lecithin:cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.43 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.43 7.4
-
 assay at Homo sapiens