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Literature summary extracted from

  • Chen, F.L.; Wang, X.Z.; Li, J.Y.; Yu, J.P.; Huang, C.Y.; Chen, Z.X.
    12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway (2008), Digest. Dis. Sci., 53, 181-187.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 baicalein
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.31 arachidonate + O2 Homo sapiens
-
 (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate further metabolized to (12S)-hydroxyeicosatetraenoate, which inhibits apoptosis in gastric cancer and activates ERK phosphorylation and the ERK1/2 signalling pathway, 12-LOX activates protein kinase C in AGS cells, overview ?
1.13.11.31 additional information Homo sapiens 12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 AGS cell
-
 Homo sapiens
-
1.13.11.31 carcinoma cell 12-LOX is overexpressed in a variety of human tumors Homo sapiens
-
1.13.11.31 gastric cancer cell 12-LOX overexpression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2
-
 Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2
-
 Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate further metabolized to (12S)-hydroxyeicosatetraenoate, which inhibits apoptosis in gastric cancer and activates ERK phosphorylation and the ERK1/2 signalling pathway, 12-LOX activates protein kinase C in AGS cells, overview ?
1.13.11.31 additional information 12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.31 ? x * 60000-80000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12-lipoxygenase
-
 Homo sapiens
1.13.11.31 12-LOX
-
 Homo sapiens