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Literature summary extracted from

  • Wiwanitkit, V.
    Plasmodium and host lactate dehydrogenase molecular function and biological pathways: implication for antimalarial drug discovery (2007), Chem. Biol. Drug Des., 69, 280-283.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.27 drug development a selective lactate dehydrogenase inhibitor targeting the L-malate dehydrogenase function of Plasmodium falciparum and its corresponding tricarboxylic acid cycle provides an attractive therapeutic opportunity, in contrast to LDH targeting due to the functional similarity between human and parasite LDHs Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 Chloroquine
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.27 (S)-lactate + NAD+ Plasmodium falciparum involved in glycolysis pyruvate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 (S)-lactate + NAD+
-
 Plasmodium falciparum pyruvate + NADH + H+
-
 r
1.1.1.27 (S)-lactate + NAD+ involved in glycolysis Plasmodium falciparum pyruvate + NADH + H+
-
 r
1.1.1.27 additional information Plasmodium falciparum lactate dehydrogenase has L-malate dehydrogenase activity, which plays a role in the tricarboxylic acid cycle Plasmodium falciparum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.27 LDH
-
 Plasmodium falciparum