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Literature summary extracted from

  • Schneider, P.; Weber, M.; Rosenberger, K.; Hoffmeister, D.
    A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones (2007), Chem. Biol., 14, 635-644.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.6.1.28 synthesis one-pot synthesis of di-demethylasterriquinone D from L-tryptophan and phenylpyruvic acid by use of enzymes TdiA and TdiD Aspergillus nidulans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.28 expression in Escherichia coli Aspergillus nidulans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.28 1.43
-
 phenylpyruvate pH 7.0, 48°C Aspergillus nidulans
2.6.1.28 3.02
-
 L-tryptophan pH 7.0, 48°C Aspergillus nidulans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.28 additional information Aspergillus nidulans catalyzes the first enzymatic step specific to the metabolic pathway toward terrequinone A ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.28 Aspergillus nidulans A7XRY8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.28 L-tryptophan + 4-hydroxyphenylpyruvate 15% of the activity with phenylpyruvate Aspergillus nidulans 3-indole-2-oxopropanoate + ?
-
 ?
2.6.1.28 L-tryptophan + phenylpyruvate
-
 Aspergillus nidulans 3-indole-2-oxopropanoate + L-phenylalanine
-
 ?
2.6.1.28 additional information catalyzes the first enzymatic step specific to the metabolic pathway toward terrequinone A Aspergillus nidulans ?
-
 ?
2.6.1.28 additional information no amino acceptor substrate: pyruvic acid, 2-oxoglutaric acid, 2-oxo-butyric acid, 2-oxo-valeric acid Aspergillus nidulans ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.28 48
-
-
 Aspergillus nidulans

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.28 9.1
-
 phenylpyruvate pH 7.0, 48°C Aspergillus nidulans
2.6.1.28 19.3
-
 L-tryptophan pH 7.0, 48°C Aspergillus nidulans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.28 7
-
-
 Aspergillus nidulans