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Literature summary extracted from

  • Pollegioni, L.; Piubelli, L.; Sacchi, S.; Pilone, M.S.; Molla, G.
    Physiological functions of D-amino acid oxidases: from yeast to humans (2007), Cell. Mol. Life Sci., 64, 1373-1394.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.3 expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.3.3 in complex with benzoate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.3 0.2
-
 D-alanine apparent value, at 25°C Cyprinus carpio
1.4.3.3 1
-
 D-alanine apparent value, at 25°C Rhodotorula toruloides
1.4.3.3 1.3
-
 D-alanine apparent value, at 25°C Homo sapiens
1.4.3.3 1.7
-
 D-alanine apparent value, at 25°C Sus scrofa
1.4.3.3 4.3
-
 D-alanine apparent value, at 25°C [Candida] boidinii
1.4.3.3 7
-
 D-alanine apparent value, at 25°C Trigonopsis variabilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.3 peroxisome
-
 Rhodotorula toruloides 5777
-
1.4.3.3 peroxisome
-
 Cyprinus carpio 5777
-
1.4.3.3 peroxisome
-
 Rattus norvegicus 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.3 40076
-
 2 * 40076, estimated from amino acid sequence Rhodotorula toruloides
1.4.3.3 80150
-
 estimated from amino acid sequence Rhodotorula toruloides

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Chlorella vulgaris
-
-
-
1.4.3.3 Cyprinus carpio Q6TGN2
-
-
1.4.3.3 Homo sapiens P14920
-
-
1.4.3.3 Mus musculus P18894
-
-
1.4.3.3 Rattus norvegicus O35078
-
-
1.4.3.3 Rhodotorula toruloides P80324 formerly Rhodotorula gracilis
-
1.4.3.3 Sus scrofa P00371
-
-
1.4.3.3 Trigonopsis variabilis Q99042
-
-
1.4.3.3 [Candida] boidinii Q9HGY3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Mus musculus
-
1.4.3.3 brain
-
 Homo sapiens
-
1.4.3.3 brain
-
 Rattus norvegicus
-
1.4.3.3 hepatocyte
-
 Rattus norvegicus
-
1.4.3.3 hepatopancreas
-
 Cyprinus carpio
-
1.4.3.3 intestine
-
 Cyprinus carpio
-
1.4.3.3 kidney
-
 Mus musculus
-
1.4.3.3 kidney
-
 Cyprinus carpio
-
1.4.3.3 kidney
-
 Sus scrofa
-
1.4.3.3 kidney
-
 Homo sapiens
-
1.4.3.3 kidney
-
 Rattus norvegicus
-
1.4.3.3 leukocyte
-
 Homo sapiens
-
1.4.3.3 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 cephalosporin C + H2O + O2
-
 Trigonopsis variabilis 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
 ?
1.4.3.3 cephalosporin C + H2O + O2
-
 Rhodotorula toruloides 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
 ?
1.4.3.3 cephalosporin C + H2O + O2
-
 Cyprinus carpio 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
 ?
1.4.3.3 cephalosporin C + H2O + O2
-
 Sus scrofa 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
 ?
1.4.3.3 cephalosporin C + H2O + O2
-
 Homo sapiens 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Trigonopsis variabilis pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 [Candida] boidinii pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Rhodotorula toruloides pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Mus musculus pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Sus scrofa pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2 best substrate Cyprinus carpio pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-leucine + H2O + O2 best substrate Chlorella vulgaris 4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-methionine + H2O + O2
-
 Sus scrofa 4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-methionine + H2O + O2 best substrate Trigonopsis variabilis 4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-methionine + H2O + O2 best substrate [Candida] boidinii 4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-naphthylalanine + H2O + O2
-
 Rhodotorula toruloides naphthylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-phenylalanine + H2O + O2
-
 Trigonopsis variabilis phenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-phenylalanine + H2O + O2
-
 Rhodotorula toruloides phenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-proline + H2O + O2
-
 Cyprinus carpio 2-oxopentanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-proline + H2O + O2 best substrate Sus scrofa 2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-proline + H2O + O2 best substrate Homo sapiens 2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 [Candida] boidinii 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2
-
 Trigonopsis variabilis indol-3-pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2
-
 Rhodotorula toruloides indol-3-pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-valine + H2O + O2
-
 Cyprinus carpio alpha-ketoisovaleric acid + NH3 + H2O2
-
 ?
1.4.3.3 D-valine + H2O + O2 best substrate Rhodotorula toruloides alpha-ketoisovaleric acid + NH3 + H2O2
-
 ?
1.4.3.3 L-DOPA + H2O + O2
-
 Homo sapiens 3,4-dihydroxyphenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 additional information the enzyme exhibits very low activity towards basic amino acids, and it does not oxidize those with an acidic side chain Sus scrofa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.3 dimer x-ray crystallography Homo sapiens
1.4.3.3 homodimer 2 * 40076, estimated from amino acid sequence Rhodotorula toruloides

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Chlorella vulgaris
1.4.3.3 D-amino acid oxidase
-
 Trigonopsis variabilis
1.4.3.3 D-amino acid oxidase
-
 [Candida] boidinii
1.4.3.3 D-amino acid oxidase
-
 Rhodotorula toruloides
1.4.3.3 D-amino acid oxidase
-
 Mus musculus
1.4.3.3 D-amino acid oxidase
-
 Cyprinus carpio
1.4.3.3 D-amino acid oxidase
-
 Sus scrofa
1.4.3.3 D-amino acid oxidase
-
 Homo sapiens
1.4.3.3 D-amino acid oxidase
-
 Rattus norvegicus
1.4.3.3 DAAO
-
 Chlorella vulgaris
1.4.3.3 DAAO
-
 Trigonopsis variabilis
1.4.3.3 DAAO
-
 [Candida] boidinii
1.4.3.3 DAAO
-
 Rhodotorula toruloides
1.4.3.3 DAAO
-
 Mus musculus
1.4.3.3 DAAO
-
 Cyprinus carpio
1.4.3.3 DAAO
-
 Sus scrofa
1.4.3.3 DAAO
-
 Homo sapiens
1.4.3.3 DAAO
-
 Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.3 5.2
-
 D-alanine apparent value, at 25°C Homo sapiens
1.4.3.3 7.3
-
 D-alanine apparent value, at 25°C Sus scrofa
1.4.3.3 46
-
 D-alanine apparent value, at 25°C Trigonopsis variabilis
1.4.3.3 80
-
 D-alanine apparent value, at 25°C [Candida] boidinii
1.4.3.3 85
-
 D-alanine apparent value, at 25°C Rhodotorula toruloides
1.4.3.3 95
-
 D-alanine apparent value, at 25°C Cyprinus carpio

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD FAD-dependent flavoenzyme Chlorella vulgaris
1.4.3.3 FAD FAD-dependent flavoenzyme Trigonopsis variabilis
1.4.3.3 FAD FAD-dependent flavoenzyme [Candida] boidinii
1.4.3.3 FAD FAD-dependent flavoenzyme Rhodotorula toruloides
1.4.3.3 FAD FAD-dependent flavoenzyme Mus musculus
1.4.3.3 FAD FAD-dependent flavoenzyme Cyprinus carpio
1.4.3.3 FAD FAD-dependent flavoenzyme Sus scrofa
1.4.3.3 FAD FAD-dependent flavoenzyme Homo sapiens
1.4.3.3 FAD FAD-dependent flavoenzyme Rattus norvegicus