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Literature summary extracted from

  • Verreth, W.; De Keyzer, D.; Davey, P.C.; Geeraert, B.; Mertens, A.; Herregods, M.C.; Smith, G.; Desjardins, F.; Balligand, J.L.; Holvoet, P.
    Rosuvastatin restores superoxide dismutase expression and inhibits accumulation of oxidized LDL in the aortic arch of obese dyslipidemic mice (2007), Br. J. Pharmacol., 151, 347-355.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.15.1.1 additional information rosuvastatin induces the enzyme in aortic extracts and restores the enzyme expression in DKO mice with combined leptin and LDL-receptor deficiency, leading to less oxLDL accumulation within atherosclerotic plaques and inhibition of plaque progression, and restores enzyme expression in THP-1 macrophages and foam cells, overview Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.15.1.1 expressed in THP-1- cells Mus musculus
1.15.1.1 expression analysis in homozygous LDL-receptor-knockout mice, heterozygous ob/+, and wild-type C57BL6 mice Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.15.1.1 additional information phenotype of homozygous LDL-receptor-knockout mice, heterozygous ob/+, and wild-type C57BL6 mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 additional information Mus musculus inverse relationship between SOD1 expression and ox-LDL in plaque plays a role in oxidative stress contributes to post-ischaemic injury in the heart, increasing SOD1 protects against this increased oxidative stress ?
-
 ?
1.15.1.1 O2.- + H+ Mus musculus rosuvastatin induces the enzyme in aortic extracts and restores the enzyme expression in mice with combined leptin and LDL-receptor deficiency, and in THP-1 macrophages and foam cells in vitro, thus, SOD1 is a potentially important mediator of the prevention of oxLDL accumulation within atherosclerotic plaques, overview O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Mus musculus
-
 homozygous LDL-receptor-knockout mice, heterozygous ob/+, and wild-type C57BL6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 aorta
-
 Mus musculus
-
1.15.1.1 foam cell
-
 Mus musculus
-
1.15.1.1 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 additional information inverse relationship between SOD1 expression and ox-LDL in plaque plays a role in oxidative stress contributes to post-ischaemic injury in the heart, increasing SOD1 protects against this increased oxidative stress Mus musculus ?
-
 ?
1.15.1.1 O2.- + H+
-
 Mus musculus O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ rosuvastatin induces the enzyme in aortic extracts and restores the enzyme expression in mice with combined leptin and LDL-receptor deficiency, and in THP-1 macrophages and foam cells in vitro, thus, SOD1 is a potentially important mediator of the prevention of oxLDL accumulation within atherosclerotic plaques, overview Mus musculus O2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 SOD1
-
 Mus musculus
1.15.1.1 superoxide dismutase 1
-
 Mus musculus